• Version:
  • 11.0 [archived version]
STRINGSTRING
NKG7 NKG7 PCDHB2 PCDHB2 HTN3 HTN3 FBXO39 FBXO39 RPL28 RPL28 ZNF132 ZNF132 KCNJ14 KCNJ14 EPN1 EPN1 YIPF2 YIPF2 SLC27A5 SLC27A5 ASB8 ASB8
"ZNF132" - Zinc finger protein 132 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF132Zinc finger protein 132; May be involved in transcriptional regulation; Zinc fingers C2H2-type (706 aa)    
Predicted Functional Partners:
SLC27A5
Bile acyl-CoA synthetase; Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol; Belongs to the ATP-dependent AMP-binding enzyme family (690 aa)
           
  0.655
HTN3
Histatin-3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 (51 aa)
           
  0.577
KCNJ14
ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] (436 aa)
           
  0.571
YIPF2
Protein YIPF2; Yip1 domain family member 2 (316 aa)
           
  0.548
NKG7
Protein NKG7; Natural killer cell granule protein 7; Belongs to the PMP-22/EMP/MP20 family (165 aa)
           
  0.476
FBXO39
F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other (442 aa)
     
 
  0.474
ASB8
Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing (288 aa)
     
 
  0.468
RPL28
60S ribosomal protein L28; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL28 family (169 aa)
           
  0.449
EPN1
Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis; Belongs to the epsin family (662 aa)
       
 
  0.408
PCDHB2
Protocadherin beta-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (798 aa)
       
 
  0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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