| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIM1 | ZNF331 | ENSP00000358062 | ENSP00000253144 | Beta/gamma crystallin domain-containing protein 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton | Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis; Zinc fingers C2H2-type | 0.608 |
| DPRX | NRDE2 | ENSP00000365838 | ENSP00000346335 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Protein NRDE2 homolog; NRDE-2, necessary for RNA interference, domain containing; Belongs to the NRDE2 family | 0.564 |
| DPRX | SPIDR | ENSP00000365838 | ENSP00000297423 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity | 0.432 |
| DPRX | ZNF331 | ENSP00000365838 | ENSP00000253144 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis; Zinc fingers C2H2-type | 0.627 |
| DUPD1 | ESPNL | ENSP00000340609 | ENSP00000339115 | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | 0.702 |
| DUPD1 | GLRB | ENSP00000340609 | ENSP00000264428 | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.605 |
| DUPD1 | ZNF331 | ENSP00000340609 | ENSP00000253144 | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis; Zinc fingers C2H2-type | 0.550 |
| DUSP27 | ESPNL | ENSP00000354483 | ENSP00000339115 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | 0.736 |
| DUSP27 | GLRB | ENSP00000354483 | ENSP00000264428 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.652 |
| DUSP27 | ZNF331 | ENSP00000354483 | ENSP00000253144 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis; Zinc fingers C2H2-type | 0.552 |
| ESPNL | DUPD1 | ENSP00000339115 | ENSP00000340609 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | 0.702 |
| ESPNL | DUSP27 | ENSP00000339115 | ENSP00000354483 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | 0.736 |
| ESPNL | GLRB | ENSP00000339115 | ENSP00000264428 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.668 |
| ESPNL | ZNF331 | ENSP00000339115 | ENSP00000253144 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis; Zinc fingers C2H2-type | 0.550 |
| GLRB | DUPD1 | ENSP00000264428 | ENSP00000340609 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | 0.605 |
| GLRB | DUSP27 | ENSP00000264428 | ENSP00000354483 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | 0.652 |
| GLRB | ESPNL | ENSP00000264428 | ENSP00000339115 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | 0.668 |
| GLRB | ZNF331 | ENSP00000264428 | ENSP00000253144 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis; Zinc fingers C2H2-type | 0.533 |
| NRDE2 | DPRX | ENSP00000346335 | ENSP00000365838 | Protein NRDE2 homolog; NRDE-2, necessary for RNA interference, domain containing; Belongs to the NRDE2 family | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | 0.564 |
| NRDE2 | SPIDR | ENSP00000346335 | ENSP00000297423 | Protein NRDE2 homolog; NRDE-2, necessary for RNA interference, domain containing; Belongs to the NRDE2 family | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity | 0.721 |
