| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CEP85 | DNAJC11 | ENSP00000252992 | ENSP00000366800 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | 0.644 |
| CEP85 | DNAJC16 | ENSP00000252992 | ENSP00000365007 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | DnaJ heat shock protein family member C16 | 0.656 |
| CEP85 | LRRC47 | ENSP00000252992 | ENSP00000367498 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47 | 0.713 |
| CEP85 | NECAP2 | ENSP00000252992 | ENSP00000391942 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Adaptin ear-binding coat-associated protein 2; Involved in endocytosis | 0.698 |
| CEP85 | NEK2 | ENSP00000252992 | ENSP00000355966 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint [...] | 0.624 |
| CEP85 | PITHD1 | ENSP00000252992 | ENSP00000246151 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | PITH domain containing 1 | 0.665 |
| CEP85 | SLC25A33 | ENSP00000252992 | ENSP00000306328 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5’-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and [...] | 0.625 |
| CEP85 | SOX13 | ENSP00000252992 | ENSP00000356172 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Transcription factor SOX-13; Binds to the sequence 5’-AACAAT-3’; SRY-boxes | 0.847 |
| CEP85 | SOX5 | ENSP00000252992 | ENSP00000398273 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.827 |
| CEP85 | WRAP73 | ENSP00000252992 | ENSP00000270708 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | WD repeat-containing protein WRAP73; The SSX2IP-WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97-CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal bo [...] | 0.668 |
| DNAJC11 | CEP85 | ENSP00000366800 | ENSP00000252992 | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | 0.644 |
| DNAJC11 | LRRC47 | ENSP00000366800 | ENSP00000367498 | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47 | 0.619 |
| DNAJC11 | NECAP2 | ENSP00000366800 | ENSP00000391942 | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | Adaptin ear-binding coat-associated protein 2; Involved in endocytosis | 0.586 |
| DNAJC11 | PITHD1 | ENSP00000366800 | ENSP00000246151 | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | PITH domain containing 1 | 0.618 |
| DNAJC11 | SLC25A33 | ENSP00000366800 | ENSP00000306328 | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5’-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and [...] | 0.573 |
| DNAJC16 | CEP85 | ENSP00000365007 | ENSP00000252992 | DnaJ heat shock protein family member C16 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | 0.656 |
| DNAJC16 | LRRC47 | ENSP00000365007 | ENSP00000367498 | DnaJ heat shock protein family member C16 | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47 | 0.574 |
| DNAJC16 | NECAP2 | ENSP00000365007 | ENSP00000391942 | DnaJ heat shock protein family member C16 | Adaptin ear-binding coat-associated protein 2; Involved in endocytosis | 0.560 |
| DNAJC16 | PITHD1 | ENSP00000365007 | ENSP00000246151 | DnaJ heat shock protein family member C16 | PITH domain containing 1 | 0.566 |
| DNAJC16 | SLC25A33 | ENSP00000365007 | ENSP00000306328 | DnaJ heat shock protein family member C16 | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5’-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and [...] | 0.482 |
