• Version:
  • 11.0 [archived version]
STRINGSTRING
ZMYM5 ZMYM5 SEC22C SEC22C SS18L2 SS18L2 TRIM28 TRIM28 TMEM89 TMEM89 ZNF557 ZNF557 MBD3L3 MBD3L3 OR4F17 OR4F17 MBD3L4 MBD3L4 MBD3L5 MBD3L5 MIER2 MIER2
"ZNF557" - Zinc finger protein 557 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF557Zinc finger protein 557; May be involved in transcriptional regulation; Zinc fingers C2H2-type (430 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
MBD3L3
methyl-CpG binding domain protein 3 like 3 (208 aa)
       
 
  0.675
MBD3L4
methyl-CpG binding domain protein 3 like 4 (208 aa)
       
 
  0.674
OR4F17
Olfactory receptor 4F17; Odorant receptor; Olfactory receptors, family 4 (305 aa)
           
  0.669
MBD3L5
methyl-CpG binding domain protein 3 like 5 (208 aa)
       
 
  0.665
SS18L2
SS18-like protein 2; SS18 like 2; Belongs to the SS18 family (77 aa)
       
 
  0.637
SEC22C
Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs (303 aa)
     
   
  0.584
MIER2
Mesoderm induction early response protein 2; Transcriptional repressor; Myb/SANT domain containing (545 aa)
       
 
  0.560
ZMYM5
Zinc finger MYM-type protein 5; Functions as a transcriptional regulator; Zinc fingers MYM-type (382 aa)
           
  0.519
TMEM89
Transmembrane protein 89 (159 aa)
           
  0.518
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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