| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABHD8 | USHBP1 | ENSP00000247706 | ENSP00000252597 | Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.542 |
| BTD | MCCC2 | ENSP00000400995 | ENSP00000343657 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Belongs to the AccD/PCCB family | 0.754 |
| BTD | USHBP1 | ENSP00000400995 | ENSP00000252597 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.757 |
| C16orf45 | USHBP1 | ENSP00000300006 | ENSP00000252597 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.572 |
| CDC42EP1 | SYBU | ENSP00000249014 | ENSP00000407118 | Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts; CDC42 effector proteins | Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development | 0.644 |
| CDC42EP1 | TLE6 | ENSP00000249014 | ENSP00000246112 | Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts; CDC42 effector proteins | Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family | 0.640 |
| CDC42EP1 | USHBP1 | ENSP00000249014 | ENSP00000252597 | Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts; CDC42 effector proteins | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.584 |
| MAGEA11 | USHBP1 | ENSP00000347358 | ENSP00000252597 | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.551 |
| MAGEA11 | ZMAT4 | ENSP00000347358 | ENSP00000297737 | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Zinc finger matrin-type 4 | 0.551 |
| MCCC2 | BTD | ENSP00000343657 | ENSP00000400995 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Belongs to the AccD/PCCB family | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.754 |
| MCCC2 | USHBP1 | ENSP00000343657 | ENSP00000252597 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Belongs to the AccD/PCCB family | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.922 |
| SYBU | CDC42EP1 | ENSP00000407118 | ENSP00000249014 | Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development | Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts; CDC42 effector proteins | 0.644 |
| SYBU | TLE6 | ENSP00000407118 | ENSP00000246112 | Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development | Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family | 0.642 |
| SYBU | USHBP1 | ENSP00000407118 | ENSP00000252597 | Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.568 |
| TLE6 | CDC42EP1 | ENSP00000246112 | ENSP00000249014 | Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family | Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts; CDC42 effector proteins | 0.640 |
| TLE6 | SYBU | ENSP00000246112 | ENSP00000407118 | Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family | Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development | 0.642 |
| TLE6 | USHBP1 | ENSP00000246112 | ENSP00000252597 | Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.674 |
| USH1C | USHBP1 | ENSP00000005226 | ENSP00000252597 | Harmonin; Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips; Deafness associated genes | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | 0.814 |
| USHBP1 | ABHD8 | ENSP00000252597 | ENSP00000247706 | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily | 0.542 |
| USHBP1 | BTD | ENSP00000252597 | ENSP00000400995 | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.757 |
