KRT75 protein (human) - STRING database

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KRT75

Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (551 aa)

Predicted Functional Partners:

KRT16

0.940

KRT17

0.937

KRT15

0.933

KRT14

0.933

KRT36

0.931

KRT35

0.930

KRT34

0.930

KRT32

0.927

KRT28

0.926

KRT9

0.926

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRT14	KRT15	ENSP00000167586	ENSP00000254043	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 15; Keratins, type I	0.934
KRT14	KRT16	ENSP00000167586	ENSP00000301653	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance	0.967
KRT14	KRT17	ENSP00000167586	ENSP00000308452	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...]	0.963
KRT14	KRT28	ENSP00000167586	ENSP00000305263	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs)	0.903
KRT14	KRT32	ENSP00000167586	ENSP00000225899	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family	0.904
KRT14	KRT34	ENSP00000167586	ENSP00000377570	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cuticular Ha4; Keratins, type I	0.904
KRT14	KRT35	ENSP00000167586	ENSP00000377558	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cuticular Ha5; Keratins, type I	0.900
KRT14	KRT36	ENSP00000167586	ENSP00000329165	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cuticular Ha6; Keratins, type I	0.900
KRT14	KRT75	ENSP00000167586	ENSP00000252245	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle	0.933
KRT14	KRT9	ENSP00000167586	ENSP00000246662	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family	0.919
KRT15	KRT14	ENSP00000254043	ENSP00000167586	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	0.934
KRT15	KRT16	ENSP00000254043	ENSP00000301653	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance	0.916
KRT15	KRT17	ENSP00000254043	ENSP00000308452	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...]	0.922
KRT15	KRT28	ENSP00000254043	ENSP00000305263	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs)	0.902
KRT15	KRT32	ENSP00000254043	ENSP00000225899	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family	0.907
KRT15	KRT34	ENSP00000254043	ENSP00000377570	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cuticular Ha4; Keratins, type I	0.904
KRT15	KRT35	ENSP00000254043	ENSP00000377558	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cuticular Ha5; Keratins, type I	0.902
KRT15	KRT36	ENSP00000254043	ENSP00000329165	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cuticular Ha6; Keratins, type I	0.903
KRT15	KRT75	ENSP00000254043	ENSP00000252245	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle	0.933
KRT15	KRT9	ENSP00000254043	ENSP00000246662	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family	0.906

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