KRT1 protein (human) - STRING database

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KRT1

Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)

Predicted Functional Partners:

KRT10

0.999

KRT5

0.997

KRT2

0.996

KRT77

0.995

KRT9

0.965

PRSS1

0.950

KRT16

0.949

KRT15

0.947

KRT13

0.946

KRT17

0.946

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRT1	KRT10	ENSP00000252244	ENSP00000269576	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 10; Keratins, type I	0.999
KRT1	KRT13	ENSP00000252244	ENSP00000246635	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 13; Keratins, type I	0.946
KRT1	KRT15	ENSP00000252244	ENSP00000254043	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 15; Keratins, type I	0.947
KRT1	KRT16	ENSP00000252244	ENSP00000301653	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance	0.949
KRT1	KRT17	ENSP00000252244	ENSP00000308452	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...]	0.946
KRT1	KRT2	ENSP00000252244	ENSP00000310861	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II	0.996
KRT1	KRT5	ENSP00000252244	ENSP00000252242	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 5; Keratins, type II	0.997
KRT1	KRT77	ENSP00000252244	ENSP00000342710	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family	0.995
KRT1	KRT9	ENSP00000252244	ENSP00000246662	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family	0.965
KRT1	PRSS1	ENSP00000252244	ENSP00000308720	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.950
KRT10	KRT1	ENSP00000269576	ENSP00000252244	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	0.999
KRT10	KRT13	ENSP00000269576	ENSP00000246635	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type I cytoskeletal 13; Keratins, type I	0.907
KRT10	KRT15	ENSP00000269576	ENSP00000254043	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type I cytoskeletal 15; Keratins, type I	0.907
KRT10	KRT16	ENSP00000269576	ENSP00000301653	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance	0.988
KRT10	KRT17	ENSP00000269576	ENSP00000308452	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...]	0.907
KRT10	KRT2	ENSP00000269576	ENSP00000310861	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II	0.995
KRT10	KRT5	ENSP00000269576	ENSP00000252242	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 5; Keratins, type II	0.995
KRT10	KRT77	ENSP00000269576	ENSP00000342710	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family	0.996
KRT10	KRT9	ENSP00000269576	ENSP00000246662	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family	0.908
KRT10	PRSS1	ENSP00000269576	ENSP00000308720	Keratin, type I cytoskeletal 10; Keratins, type I	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.957

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