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  • 11.0 [archived version]
STRINGSTRING
TTC14 TTC14 FRA10AC1 FRA10AC1 PRPF19 PRPF19 ENSG00000280071 ENSG00000280071 SLC2A13 SLC2A13 DGCR14 DGCR14 C21orf33 C21orf33 UFD1L UFD1L HIRA HIRA SLC25A1 SLC25A1 DGCR2 DGCR2
"DGCR14" - Protein DGCR14 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
DGCR14Protein DGCR14; May be involved in pre-mRNA splicing (476 aa)    
Predicted Functional Partners:
ENSG00000280071
annotation not available (268 aa)
           
  0.898
C21orf33
ES1 protein homolog, mitochondrial; Glutamine amidotransferase like class 1 domain containing (268 aa)
           
  0.897
PRPF19
Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] (504 aa)
     
 
  0.892
FRA10AC1
Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex (315 aa)
       
 
  0.828
DGCR2
Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing (550 aa)
     
   
  0.754
SLC25A1
Tricarboxylate transport protein, mitochondrial; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway; Solute carriers (311 aa)
           
  0.754
SLC2A13
Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family (648 aa)
       
      0.731
HIRA
Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; WD repeat domain containing (1017 aa)
     
   
  0.723
TTC14
Tetratricopeptide repeat domain containing (770 aa)
       
      0.656
UFD1L
Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...] (307 aa)
           
  0.654
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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