node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C21orf33 | DGCR14 | ENSP00000291577 | ENSP00000252137 | ES1 protein homolog, mitochondrial; Glutamine amidotransferase like class 1 domain containing | Protein DGCR14; May be involved in pre-mRNA splicing | 0.897 |
DGCR14 | C21orf33 | ENSP00000252137 | ENSP00000291577 | Protein DGCR14; May be involved in pre-mRNA splicing | ES1 protein homolog, mitochondrial; Glutamine amidotransferase like class 1 domain containing | 0.897 |
DGCR14 | DGCR2 | ENSP00000252137 | ENSP00000263196 | Protein DGCR14; May be involved in pre-mRNA splicing | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | 0.754 |
DGCR14 | ENSG00000280071 | ENSP00000252137 | ENSP00000480313 | Protein DGCR14; May be involved in pre-mRNA splicing | annotation not available | 0.898 |
DGCR14 | FRA10AC1 | ENSP00000252137 | ENSP00000360488 | Protein DGCR14; May be involved in pre-mRNA splicing | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | 0.828 |
DGCR14 | HIRA | ENSP00000252137 | ENSP00000263208 | Protein DGCR14; May be involved in pre-mRNA splicing | Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; WD repeat domain containing | 0.723 |
DGCR14 | PRPF19 | ENSP00000252137 | ENSP00000227524 | Protein DGCR14; May be involved in pre-mRNA splicing | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] | 0.892 |
DGCR14 | SLC25A1 | ENSP00000252137 | ENSP00000215882 | Protein DGCR14; May be involved in pre-mRNA splicing | Tricarboxylate transport protein, mitochondrial; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway; Solute carriers | 0.754 |
DGCR14 | SLC2A13 | ENSP00000252137 | ENSP00000280871 | Protein DGCR14; May be involved in pre-mRNA splicing | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family | 0.731 |
DGCR14 | TTC14 | ENSP00000252137 | ENSP00000296015 | Protein DGCR14; May be involved in pre-mRNA splicing | Tetratricopeptide repeat domain containing | 0.656 |
DGCR14 | UFD1L | ENSP00000252137 | ENSP00000263202 | Protein DGCR14; May be involved in pre-mRNA splicing | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...] | 0.654 |
DGCR2 | DGCR14 | ENSP00000263196 | ENSP00000252137 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Protein DGCR14; May be involved in pre-mRNA splicing | 0.754 |
DGCR2 | HIRA | ENSP00000263196 | ENSP00000263208 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; WD repeat domain containing | 0.759 |
DGCR2 | SLC25A1 | ENSP00000263196 | ENSP00000215882 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Tricarboxylate transport protein, mitochondrial; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway; Solute carriers | 0.656 |
DGCR2 | UFD1L | ENSP00000263196 | ENSP00000263202 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...] | 0.621 |
ENSG00000280071 | DGCR14 | ENSP00000480313 | ENSP00000252137 | annotation not available | Protein DGCR14; May be involved in pre-mRNA splicing | 0.898 |
FRA10AC1 | DGCR14 | ENSP00000360488 | ENSP00000252137 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | Protein DGCR14; May be involved in pre-mRNA splicing | 0.828 |
FRA10AC1 | TTC14 | ENSP00000360488 | ENSP00000296015 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | Tetratricopeptide repeat domain containing | 0.514 |
HIRA | DGCR14 | ENSP00000263208 | ENSP00000252137 | Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; WD repeat domain containing | Protein DGCR14; May be involved in pre-mRNA splicing | 0.723 |
HIRA | DGCR2 | ENSP00000263208 | ENSP00000263196 | Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; WD repeat domain containing | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | 0.759 |