| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL3 | C20orf194 | ENSP00000260746 | ENSP00000252032 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | Uncharacterized protein C20orf194; May act as an effector for ARL3 | 0.583 |
| ARL3 | CFAP36 | ENSP00000260746 | ENSP00000342699 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | 0.947 |
| C20orf194 | ARL3 | ENSP00000252032 | ENSP00000260746 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | 0.583 |
| C20orf194 | CFAP36 | ENSP00000252032 | ENSP00000342699 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | 0.590 |
| C20orf194 | DSEL | ENSP00000252032 | ENSP00000310565 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family | 0.646 |
| C20orf194 | ETNPPL | ENSP00000252032 | ENSP00000296486 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | 0.544 |
| C20orf194 | GABRE | ENSP00000252032 | ENSP00000359353 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.541 |
| C20orf194 | ITPA | ENSP00000252032 | ENSP00000369456 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2’-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5’-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions | 0.557 |
| C20orf194 | ITSN1 | ENSP00000252032 | ENSP00000370719 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Intersectin-1; Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1; C2 domain co [...] | 0.604 |
| C20orf194 | MAP3K14 | ENSP00000252032 | ENSP00000482657 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non- canonical pathway. Could act in a receptor-selective manner; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | 0.634 |
| C20orf194 | TTBK1 | ENSP00000252032 | ENSP00000259750 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family | 0.694 |
| C20orf194 | VPS26A | ENSP00000252032 | ENSP00000362480 | Uncharacterized protein C20orf194; May act as an effector for ARL3 | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.612 |
| CFAP36 | ARL3 | ENSP00000342699 | ENSP00000260746 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | 0.947 |
| CFAP36 | C20orf194 | ENSP00000342699 | ENSP00000252032 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | Uncharacterized protein C20orf194; May act as an effector for ARL3 | 0.590 |
| DSEL | C20orf194 | ENSP00000310565 | ENSP00000252032 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family | Uncharacterized protein C20orf194; May act as an effector for ARL3 | 0.646 |
| DSEL | GABRE | ENSP00000310565 | ENSP00000359353 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.644 |
| DSEL | ITSN1 | ENSP00000310565 | ENSP00000370719 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family | Intersectin-1; Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1; C2 domain co [...] | 0.683 |
| DSEL | MAP3K14 | ENSP00000310565 | ENSP00000482657 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family | Mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non- canonical pathway. Could act in a receptor-selective manner; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | 0.595 |
| DSEL | TTBK1 | ENSP00000310565 | ENSP00000259750 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family | 0.724 |
| DSEL | VPS26A | ENSP00000310565 | ENSP00000362480 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.710 |
