| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARPP21 | KIAA0930 | ENSP00000412326 | ENSP00000251993 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons | Uncharacterized protein KIAA0930; KIAA0930 | 0.691 |
| ARPP21 | SKA2 | ENSP00000412326 | ENSP00000333433 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons | Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] | 0.589 |
| CEP104 | DPY19L3 | ENSP00000367476 | ENSP00000344937 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | 0.582 |
| CEP104 | KIAA0930 | ENSP00000367476 | ENSP00000251993 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Uncharacterized protein KIAA0930; KIAA0930 | 0.541 |
| CEP104 | USP6NL | ENSP00000367476 | ENSP00000277575 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex | 0.553 |
| DPY19L3 | CEP104 | ENSP00000344937 | ENSP00000367476 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | 0.582 |
| DPY19L3 | KIAA0930 | ENSP00000344937 | ENSP00000251993 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | Uncharacterized protein KIAA0930; KIAA0930 | 0.581 |
| DPY19L3 | USP6NL | ENSP00000344937 | ENSP00000277575 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex | 0.573 |
| KIAA0930 | ARPP21 | ENSP00000251993 | ENSP00000412326 | Uncharacterized protein KIAA0930; KIAA0930 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons | 0.691 |
| KIAA0930 | CEP104 | ENSP00000251993 | ENSP00000367476 | Uncharacterized protein KIAA0930; KIAA0930 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | 0.541 |
| KIAA0930 | DPY19L3 | ENSP00000251993 | ENSP00000344937 | Uncharacterized protein KIAA0930; KIAA0930 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | 0.581 |
| KIAA0930 | SFN | ENSP00000251993 | ENSP00000340989 | Uncharacterized protein KIAA0930; KIAA0930 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family | 0.823 |
| KIAA0930 | SKA2 | ENSP00000251993 | ENSP00000333433 | Uncharacterized protein KIAA0930; KIAA0930 | Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] | 0.728 |
| KIAA0930 | USP6NL | ENSP00000251993 | ENSP00000277575 | Uncharacterized protein KIAA0930; KIAA0930 | USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex | 0.619 |
| KIAA0930 | YWHAB | ENSP00000251993 | ENSP00000361930 | Uncharacterized protein KIAA0930; KIAA0930 | 14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulato [...] | 0.534 |
| KIAA0930 | YWHAG | ENSP00000251993 | ENSP00000306330 | Uncharacterized protein KIAA0930; KIAA0930 | 14-3-3 protein gamma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family | 0.674 |
| KIAA0930 | YWHAQ | ENSP00000251993 | ENSP00000371267 | Uncharacterized protein KIAA0930; KIAA0930 | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1; Belongs to the 14-3-3 family | 0.813 |
| KIAA0930 | YWHAZ | ENSP00000251993 | ENSP00000379287 | Uncharacterized protein KIAA0930; KIAA0930 | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family | 0.664 |
| SFN | KIAA0930 | ENSP00000340989 | ENSP00000251993 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family | Uncharacterized protein KIAA0930; KIAA0930 | 0.823 |
| SFN | YWHAB | ENSP00000340989 | ENSP00000361930 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family | 14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulato [...] | 0.968 |
