NXPE1 protein (human) - STRING database

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NXPE1

NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family (405 aa)

Predicted Functional Partners:

NXPE4

0.562

COLCA2

0.559

EXD2

0.535

TIMM10B

0.529

HEPACAM2

0.526

MLH1

0.480

THAP11

0.430

LGALS2

0.428

WBP1L

0.426

NXPH2

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COLCA2	NXPE1	ENSP00000484135	ENSP00000251921	Colorectal cancer associated 2	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	0.559
COLCA2	WBP1L	ENSP00000484135	ENSP00000414721	Colorectal cancer associated 2	WW domain binding protein 1 like; WBP1/VOPP1 family	0.717
EXD2	NXPE1	ENSP00000313140	ENSP00000251921	Exonuclease 3’-5’ domain-containing protein 2; Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks; Belongs to the EXD2 family	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	0.535
EXD2	THAP11	ENSP00000313140	ENSP00000304689	Exonuclease 3’-5’ domain-containing protein 2; Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks; Belongs to the EXD2 family	THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing	0.535
EXD2	TIMM10B	ENSP00000313140	ENSP00000254616	Exonuclease 3’-5’ domain-containing protein 2; Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks; Belongs to the EXD2 family	Mitochondrial import inner membrane translocase subunit Tim10 B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space	0.527
EXD2	WBP1L	ENSP00000313140	ENSP00000414721	Exonuclease 3’-5’ domain-containing protein 2; Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks; Belongs to the EXD2 family	WW domain binding protein 1 like; WBP1/VOPP1 family	0.672
HEPACAM2	NXPE1	ENSP00000390204	ENSP00000251921	HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes- anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation; I-set domain containing	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	0.526
LGALS2	NXPE1	ENSP00000215886	ENSP00000251921	Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	0.428
MLH1	NXPE1	ENSP00000231790	ENSP00000251921	DNA mismatch repair protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing [...]	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	0.480
NXPE1	COLCA2	ENSP00000251921	ENSP00000484135	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	Colorectal cancer associated 2	0.559
NXPE1	EXD2	ENSP00000251921	ENSP00000313140	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	Exonuclease 3’-5’ domain-containing protein 2; Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks; Belongs to the EXD2 family	0.535
NXPE1	HEPACAM2	ENSP00000251921	ENSP00000390204	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes- anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation; I-set domain containing	0.526
NXPE1	LGALS2	ENSP00000251921	ENSP00000215886	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins	0.428
NXPE1	MLH1	ENSP00000251921	ENSP00000231790	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	DNA mismatch repair protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing [...]	0.480
NXPE1	NXPE4	ENSP00000251921	ENSP00000364627	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family	0.562
NXPE1	NXPH2	ENSP00000251921	ENSP00000272641	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family	0.416
NXPE1	THAP11	ENSP00000251921	ENSP00000304689	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing	0.430
NXPE1	TIMM10B	ENSP00000251921	ENSP00000254616	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	Mitochondrial import inner membrane translocase subunit Tim10 B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space	0.529
NXPE1	WBP1L	ENSP00000251921	ENSP00000414721	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	WW domain binding protein 1 like; WBP1/VOPP1 family	0.426
NXPE4	NXPE1	ENSP00000364627	ENSP00000251921	NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family	NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family	0.562

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