• Version:
  • 11.0 [archived version]
STRINGSTRING
SACM1L SACM1L SYT16 SYT16 DERL1 DERL1 ESYT3 ESYT3 ESYT1 ESYT1 SYT14 SYT14 ESYT2 ESYT2 WDR60 WDR60 VWC2L VWC2L RPH3AL RPH3AL SYT13 SYT13
"ESYT2" - Extended synaptotagmin-2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ESYT2Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex; Extended synaptotagmins (893 aa)    
Predicted Functional Partners:
ESYT1
Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family (1114 aa)
     
0.986
ESYT3
Extended synaptotagmin-3; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Extended synaptotagmins (886 aa)
     
0.941
DERL1
Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for prot [...] (251 aa)
       
 
  0.861
SYT14
Synaptotagmin-14; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent; Belongs to the synaptotagmin family (574 aa)
           
  0.761
WDR60
WD repeat-containing protein 60; May play a role in ciliogenesis; WD repeat domain containing (1066 aa)
     
   
  0.690
VWC2L
Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization (222 aa)
           
  0.686
SYT16
Synaptotagmin-16; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent; Synaptotagmins (645 aa)
           
  0.655
SYT13
Synaptotagmin-13; May be involved in transport vesicle docking to the plasma membrane; Belongs to the synaptotagmin family (426 aa)
           
  0.591
SACM1L
Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Has low activity towards PtdIns(3,5)P2 (By similarity) (587 aa)
     
 
  0.589
RPH3AL
Rab effector Noc2; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells (315 aa)
           
  0.587
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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