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  • 11.0 [archived version]
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GFI1B GFI1B SMARCD3 SMARCD3 PKD1 PKD1 RBM23 RBM23 THOC6 THOC6 MEGF8 MEGF8 DMRTC2 DMRTC2 TMEM145 TMEM145 PSG1 PSG1 PSG8 PSG8 MGRN1 MGRN1
"MEGF8" - Multiple epidermal growth factor-like domains protein 8 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MEGF8Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 (2845 aa)    
Predicted Functional Partners:
MGRN1
E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins (576 aa)
     
 
  0.901
PSG1
Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family (428 aa)
       
 
  0.786
PKD1
Polycystin-1; Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be a [...] (4303 aa)
     
        0.779
SMARCD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- spe [...] (483 aa)
     
   
  0.754
GFI1B
Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] (330 aa)
       
 
  0.732
PSG8
Pregnancy specific beta-1-glycoprotein 8 (426 aa)
       
 
  0.684
DMRTC2
Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family (367 aa)
           
  0.622
TMEM145
Transmembrane protein 145 (493 aa)
           
  0.581
THOC6
THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential [...] (341 aa)
           
  0.565
RBM23
Probable RNA-binding protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process; Belongs to the splicing factor SR family (439 aa)
           
  0.558
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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