node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMRTC2 | MEGF8 | ENSP00000269945 | ENSP00000251268 | Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | 0.622 |
GFI1B | MEGF8 | ENSP00000344782 | ENSP00000251268 | Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | 0.732 |
GFI1B | SMARCD3 | ENSP00000344782 | ENSP00000262188 | Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- spe [...] | 0.468 |
MEGF8 | DMRTC2 | ENSP00000251268 | ENSP00000269945 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family | 0.622 |
MEGF8 | GFI1B | ENSP00000251268 | ENSP00000344782 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] | 0.732 |
MEGF8 | MGRN1 | ENSP00000251268 | ENSP00000262370 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins | 0.901 |
MEGF8 | PKD1 | ENSP00000251268 | ENSP00000262304 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | Polycystin-1; Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be a [...] | 0.779 |
MEGF8 | PSG1 | ENSP00000251268 | ENSP00000308970 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family | 0.786 |
MEGF8 | PSG8 | ENSP00000251268 | ENSP00000305005 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | Pregnancy specific beta-1-glycoprotein 8 | 0.684 |
MEGF8 | RBM23 | ENSP00000251268 | ENSP00000352956 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | Probable RNA-binding protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process; Belongs to the splicing factor SR family | 0.558 |
MEGF8 | SMARCD3 | ENSP00000251268 | ENSP00000262188 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- spe [...] | 0.754 |
MEGF8 | THOC6 | ENSP00000251268 | ENSP00000326531 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential [...] | 0.565 |
MEGF8 | TMEM145 | ENSP00000251268 | ENSP00000301204 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | Transmembrane protein 145 | 0.581 |
MGRN1 | MEGF8 | ENSP00000262370 | ENSP00000251268 | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | 0.901 |
MGRN1 | PSG8 | ENSP00000262370 | ENSP00000305005 | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins | Pregnancy specific beta-1-glycoprotein 8 | 0.518 |
PKD1 | MEGF8 | ENSP00000262304 | ENSP00000251268 | Polycystin-1; Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear- mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be a [...] | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | 0.779 |
PSG1 | MEGF8 | ENSP00000308970 | ENSP00000251268 | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | 0.786 |
PSG1 | PSG8 | ENSP00000308970 | ENSP00000305005 | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family | Pregnancy specific beta-1-glycoprotein 8 | 0.750 |
PSG8 | MEGF8 | ENSP00000305005 | ENSP00000251268 | Pregnancy specific beta-1-glycoprotein 8 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 | 0.684 |
PSG8 | MGRN1 | ENSP00000305005 | ENSP00000262370 | Pregnancy specific beta-1-glycoprotein 8 | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins | 0.518 |