DTWD1 protein (human) - STRING database

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DTWD1

DTW domain containing 1; Belongs to the DTW family (304 aa)

Predicted Functional Partners:

TMC2

0.762

SECISBP2L

0.677

SPEF1

0.548

ENSG00000086848

0.534

TMC1

0.530

TSR3

0.499

SPPL2A

0.494

PLAC9

0.491

ABCB8

0.487

DTWD2

0.486

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB8	DTWD1	ENSP00000297504	ENSP00000251250	ATP-binding cassette sub-family B member 8, mitochondrial; ATP binding cassette subfamily B member 8; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily	DTW domain containing 1; Belongs to the DTW family	0.487
DTWD1	ABCB8	ENSP00000251250	ENSP00000297504	DTW domain containing 1; Belongs to the DTW family	ATP-binding cassette sub-family B member 8, mitochondrial; ATP binding cassette subfamily B member 8; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily	0.487
DTWD1	DTWD2	ENSP00000251250	ENSP00000425048	DTW domain containing 1; Belongs to the DTW family	DTW domain containing 2	0.486
DTWD1	ENSG00000086848	ENSP00000251250	ENSP00000482396	DTW domain containing 1; Belongs to the DTW family	Alpha-1,2-mannosyltransferase ALG9; Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; Belongs to the glycosyltransferase 22 family	0.534
DTWD1	PLAC9	ENSP00000251250	ENSP00000361337	DTW domain containing 1; Belongs to the DTW family	Placenta-specific protein 9; Placenta specific 9; Belongs to the PLAC9 family	0.491
DTWD1	SECISBP2L	ENSP00000251250	ENSP00000453854	DTW domain containing 1; Belongs to the DTW family	Selenocysteine insertion sequence-binding protein 2-like; Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro	0.677
DTWD1	SPEF1	ENSP00000251250	ENSP00000369080	DTW domain containing 1; Belongs to the DTW family	Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule- associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity)	0.548
DTWD1	SPPL2A	ENSP00000251250	ENSP00000261854	DTW domain containing 1; Belongs to the DTW family	Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...]	0.494
DTWD1	TMC1	ENSP00000251250	ENSP00000297784	DTW domain containing 1; Belongs to the DTW family	Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family	0.530
DTWD1	TMC2	ENSP00000251250	ENSP00000351732	DTW domain containing 1; Belongs to the DTW family	Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell’s mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity); Transmembrane channel likes	0.762
DTWD1	TSR3	ENSP00000251250	ENSP00000007390	DTW domain containing 1; Belongs to the DTW family	Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis	0.499
DTWD2	DTWD1	ENSP00000425048	ENSP00000251250	DTW domain containing 2	DTW domain containing 1; Belongs to the DTW family	0.486
DTWD2	TSR3	ENSP00000425048	ENSP00000007390	DTW domain containing 2	Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis	0.415
ENSG00000086848	DTWD1	ENSP00000482396	ENSP00000251250	Alpha-1,2-mannosyltransferase ALG9; Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; Belongs to the glycosyltransferase 22 family	DTW domain containing 1; Belongs to the DTW family	0.534
PLAC9	DTWD1	ENSP00000361337	ENSP00000251250	Placenta-specific protein 9; Placenta specific 9; Belongs to the PLAC9 family	DTW domain containing 1; Belongs to the DTW family	0.491
SECISBP2L	DTWD1	ENSP00000453854	ENSP00000251250	Selenocysteine insertion sequence-binding protein 2-like; Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro	DTW domain containing 1; Belongs to the DTW family	0.677
SPEF1	DTWD1	ENSP00000369080	ENSP00000251250	Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule- associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity)	DTW domain containing 1; Belongs to the DTW family	0.548
SPPL2A	DTWD1	ENSP00000261854	ENSP00000251250	Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...]	DTW domain containing 1; Belongs to the DTW family	0.494
TMC1	DTWD1	ENSP00000297784	ENSP00000251250	Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family	DTW domain containing 1; Belongs to the DTW family	0.530
TMC2	DTWD1	ENSP00000351732	ENSP00000251250	Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell’s mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity); Transmembrane channel likes	DTW domain containing 1; Belongs to the DTW family	0.762

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