EAPP protein (human) - STRING database

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EAPP

E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (285 aa)

Predicted Functional Partners:

AAR2

0.910

PRPF8

0.882

SNRNP200

0.876

EFTUD2

0.873

DHX35

0.865

TSSC4

0.845

GPATCH1

0.834

ECD

0.812

CRNKL1

0.748

DDX23

0.735

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAR2	CRNKL1	ENSP00000363043	ENSP00000366557	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	0.632
AAR2	DDX23	ENSP00000363043	ENSP00000310723	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation; DEAD-box helicases	0.884
AAR2	EAPP	ENSP00000363043	ENSP00000250454	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression	0.910
AAR2	ECD	ENSP00000363043	ENSP00000401566	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	Protein ecdysoneless homolog; Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the [...]	0.869
AAR2	EFTUD2	ENSP00000363043	ENSP00000392094	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.995
AAR2	PRPF8	ENSP00000363043	ENSP00000460348	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	Pre-mRNA-processing-splicing factor 8; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site	0.995
AAR2	SNRNP200	ENSP00000363043	ENSP00000317123	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.984
AAR2	TSSC4	ENSP00000363043	ENSP00000331087	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	Protein TSSC4; Tumor suppressing subtransferable candidate 4	0.927
CRNKL1	AAR2	ENSP00000366557	ENSP00000363043	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	0.632
CRNKL1	DDX23	ENSP00000366557	ENSP00000310723	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation; DEAD-box helicases	0.984
CRNKL1	DHX35	ENSP00000366557	ENSP00000252011	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily	0.863
CRNKL1	EAPP	ENSP00000366557	ENSP00000250454	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression	0.748
CRNKL1	EFTUD2	ENSP00000366557	ENSP00000392094	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.999
CRNKL1	PRPF8	ENSP00000366557	ENSP00000460348	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Pre-mRNA-processing-splicing factor 8; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site	0.999
CRNKL1	SNRNP200	ENSP00000366557	ENSP00000317123	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.999
CRNKL1	TSSC4	ENSP00000366557	ENSP00000331087	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Protein TSSC4; Tumor suppressing subtransferable candidate 4	0.535
DDX23	AAR2	ENSP00000310723	ENSP00000363043	Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation; DEAD-box helicases	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing	0.884
DDX23	CRNKL1	ENSP00000310723	ENSP00000366557	Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation; DEAD-box helicases	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	0.984
DDX23	DHX35	ENSP00000310723	ENSP00000252011	Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation; DEAD-box helicases	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily	0.752
DDX23	EAPP	ENSP00000310723	ENSP00000250454	Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation; DEAD-box helicases	E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression	0.735

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