node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLCN6 | CLN3 | ENSP00000234488 | ENSP00000454229 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | 0.579 |
CLCN6 | CLN5 | ENSP00000234488 | ENSP00000366673 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | 0.781 |
CLCN6 | CLN6 | ENSP00000234488 | ENSP00000249806 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | CLN6, transmembrane ER protein | 0.794 |
CLCN6 | CLN8 | ENSP00000234488 | ENSP00000328182 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing | 0.552 |
CLCN6 | ENSG00000261832 | ENSP00000234488 | ENSP00000485589 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | Battenin isoform d | 0.546 |
CLCN6 | MFSD8 | ENSP00000234488 | ENSP00000296468 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily | 0.604 |
CLCN6 | PPT1 | ENSP00000234488 | ENSP00000394863 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family | 0.565 |
CLCN6 | SGSH | ENSP00000234488 | ENSP00000314606 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation; Belongs to the sulfatase family | 0.777 |
CLN3 | CLCN6 | ENSP00000454229 | ENSP00000234488 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | 0.579 |
CLN3 | CLN5 | ENSP00000454229 | ENSP00000366673 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | 0.910 |
CLN3 | CLN6 | ENSP00000454229 | ENSP00000249806 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | CLN6, transmembrane ER protein | 0.895 |
CLN3 | CLN8 | ENSP00000454229 | ENSP00000328182 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing | 0.870 |
CLN3 | DNAJC5 | ENSP00000454229 | ENSP00000354111 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity); DNAJ heat shock proteins | 0.718 |
CLN3 | MFSD8 | ENSP00000454229 | ENSP00000296468 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily | 0.846 |
CLN3 | PPT1 | ENSP00000454229 | ENSP00000394863 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family | 0.907 |
CLN3 | SGSH | ENSP00000454229 | ENSP00000314606 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation; Belongs to the sulfatase family | 0.535 |
CLN3 | TPP1 | ENSP00000454229 | ENSP00000299427 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) | 0.766 |
CLN5 | CLCN6 | ENSP00000366673 | ENSP00000234488 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter; Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily | 0.781 |
CLN5 | CLN3 | ENSP00000366673 | ENSP00000454229 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | 0.910 |
CLN5 | CLN6 | ENSP00000366673 | ENSP00000249806 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | CLN6, transmembrane ER protein | 0.934 |