STRIP2 protein (human) - STRING database

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STRIP2

Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Belongs to the STRIP family (834 aa)

Predicted Functional Partners:

STRN

0.973

STRN3

0.965

MOB4

0.962

MST4

0.961

CTTNBP2NL

0.958

SIKE1

0.954

STK25

0.945

STK24

0.943

CTTNBP2

0.915

STK3

0.889

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTTNBP2	CTTNBP2NL	ENSP00000160373	ENSP00000271277	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	0.872
CTTNBP2	MOB4	ENSP00000160373	ENSP00000315702	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	0.910
CTTNBP2	MST4	ENSP00000160373	ENSP00000377867	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily	0.909
CTTNBP2	SIKE1	ENSP00000160373	ENSP00000358541	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways; Belongs to the SIKE family	0.465
CTTNBP2	STK24	ENSP00000160373	ENSP00000365730	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Serine/threonine-protein kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and sti [...]	0.891
CTTNBP2	STK25	ENSP00000160373	ENSP00000325748	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration	0.889
CTTNBP2	STK3	ENSP00000160373	ENSP00000429744	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Serine/threonine-protein kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...]	0.863
CTTNBP2	STRIP2	ENSP00000160373	ENSP00000249344	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Belongs to the STRIP family	0.915
CTTNBP2	STRN	ENSP00000160373	ENSP00000263918	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family	0.947
CTTNBP2	STRN3	ENSP00000160373	ENSP00000350071	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Protein phosphatase 2 regulatory subunits	0.906
CTTNBP2NL	CTTNBP2	ENSP00000271277	ENSP00000160373	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin repeat domain containing	0.872
CTTNBP2NL	MOB4	ENSP00000271277	ENSP00000315702	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family	0.952
CTTNBP2NL	MST4	ENSP00000271277	ENSP00000377867	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily	0.929
CTTNBP2NL	SIKE1	ENSP00000271277	ENSP00000358541	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways; Belongs to the SIKE family	0.570
CTTNBP2NL	STK24	ENSP00000271277	ENSP00000365730	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and sti [...]	0.908
CTTNBP2NL	STK25	ENSP00000271277	ENSP00000325748	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration	0.904
CTTNBP2NL	STK3	ENSP00000271277	ENSP00000429744	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Serine/threonine-protein kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...]	0.861
CTTNBP2NL	STRIP2	ENSP00000271277	ENSP00000249344	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Belongs to the STRIP family	0.958
CTTNBP2NL	STRN	ENSP00000271277	ENSP00000263918	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family	0.954
CTTNBP2NL	STRN3	ENSP00000271277	ENSP00000350071	CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex	Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Protein phosphatase 2 regulatory subunits	0.942

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