CCDC117 protein (human) - STRING database

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CCDC117

Coiled-coil domain containing 117 (279 aa)

Predicted Functional Partners:

STIP1

0.772

LRRN1

0.563

LRCH4

0.558

YPEL2

0.548

HSP90AA1

0.546

ZMYND11

0.530

ELOVL2

0.487

SLC39A6

0.485

ZBTB40

0.482

KHDRBS1

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC117	ELOVL2	ENSP00000249064	ENSP00000346693	Coiled-coil domain containing 117	Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n- 6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate in the production of polyuns [...]	0.487
CCDC117	HSP90AA1	ENSP00000249064	ENSP00000335153	Coiled-coil domain containing 117	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.546
CCDC117	KHDRBS1	ENSP00000249064	ENSP00000313829	Coiled-coil domain containing 117	KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediate [...]	0.473
CCDC117	LRCH4	ENSP00000249064	ENSP00000309689	Coiled-coil domain containing 117	Leucine rich repeats and calponin homology domain containing 4	0.558
CCDC117	LRRN1	ENSP00000249064	ENSP00000314901	Coiled-coil domain containing 117	Leucine rich repeat neuronal 1; I-set domain containing	0.563
CCDC117	SLC39A6	ENSP00000249064	ENSP00000269187	Coiled-coil domain containing 117	Zinc transporter ZIP6; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family	0.485
CCDC117	STIP1	ENSP00000249064	ENSP00000351646	Coiled-coil domain containing 117	Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity); Tetratricopeptide repeat domain containing	0.772
CCDC117	YPEL2	ENSP00000249064	ENSP00000312272	Coiled-coil domain containing 117	Protein yippee-like 2; Yippee like family	0.548
CCDC117	ZBTB40	ENSP00000249064	ENSP00000384527	Coiled-coil domain containing 117	Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation; BTB domain containing	0.482
CCDC117	ZMYND11	ENSP00000249064	ENSP00000381053	Coiled-coil domain containing 117	Zinc finger MYND domain-containing protein 11; Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at ’Lys-36’ (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non- specifically to dsDNA. Acts as a tumor- suppressor by repressing a transcriptional program essential for tumor cell growth; Bromodomain containing	0.530
ELOVL2	CCDC117	ENSP00000346693	ENSP00000249064	Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n- 6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate in the production of polyuns [...]	Coiled-coil domain containing 117	0.487
HSP90AA1	CCDC117	ENSP00000335153	ENSP00000249064	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	Coiled-coil domain containing 117	0.546
HSP90AA1	STIP1	ENSP00000335153	ENSP00000351646	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity); Tetratricopeptide repeat domain containing	0.999
KHDRBS1	CCDC117	ENSP00000313829	ENSP00000249064	KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediate [...]	Coiled-coil domain containing 117	0.473
LRCH4	CCDC117	ENSP00000309689	ENSP00000249064	Leucine rich repeats and calponin homology domain containing 4	Coiled-coil domain containing 117	0.558
LRRN1	CCDC117	ENSP00000314901	ENSP00000249064	Leucine rich repeat neuronal 1; I-set domain containing	Coiled-coil domain containing 117	0.563
SLC39A6	CCDC117	ENSP00000269187	ENSP00000249064	Zinc transporter ZIP6; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family	Coiled-coil domain containing 117	0.485
STIP1	CCDC117	ENSP00000351646	ENSP00000249064	Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity); Tetratricopeptide repeat domain containing	Coiled-coil domain containing 117	0.772
STIP1	HSP90AA1	ENSP00000351646	ENSP00000335153	Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity); Tetratricopeptide repeat domain containing	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.999
YPEL2	CCDC117	ENSP00000312272	ENSP00000249064	Protein yippee-like 2; Yippee like family	Coiled-coil domain containing 117	0.548

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