| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADRBK2 | MYO18A | ENSP00000317578 | ENSP00000437073 | Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors | Unconventional myosin-XVIIIa; May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates t [...] | 0.470 |
| ADRBK2 | MYO18B | ENSP00000317578 | ENSP00000334563 | Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.901 |
| ADRBK2 | SEZ6L | ENSP00000317578 | ENSP00000248933 | Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.902 |
| BACE2 | RTN1 | ENSP00000332979 | ENSP00000267484 | Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 | Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | 0.616 |
| BACE2 | SEZ6L | ENSP00000332979 | ENSP00000248933 | Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.723 |
| C3orf62 | CCDC36 | ENSP00000341139 | ENSP00000391788 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | 0.624 |
| C3orf62 | MYO18B | ENSP00000341139 | ENSP00000334563 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.529 |
| C3orf62 | SEZ6L | ENSP00000341139 | ENSP00000248933 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.626 |
| C5orf47 | SEZ6L | ENSP00000340887 | ENSP00000248933 | Uncharacterized protein C5orf47; Chromosome 5 open reading frame 47 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.512 |
| CCDC36 | C3orf62 | ENSP00000391788 | ENSP00000341139 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.624 |
| CCDC36 | MYO18B | ENSP00000391788 | ENSP00000334563 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.677 |
| CCDC36 | SEZ6L | ENSP00000391788 | ENSP00000248933 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.682 |
| MYO18A | ADRBK2 | ENSP00000437073 | ENSP00000317578 | Unconventional myosin-XVIIIa; May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates t [...] | Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors | 0.470 |
| MYO18A | SEZ6L | ENSP00000437073 | ENSP00000248933 | Unconventional myosin-XVIIIa; May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates t [...] | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.529 |
| MYO18B | ADRBK2 | ENSP00000334563 | ENSP00000317578 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors | 0.901 |
| MYO18B | C3orf62 | ENSP00000334563 | ENSP00000341139 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.529 |
| MYO18B | CCDC36 | ENSP00000334563 | ENSP00000391788 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | 0.677 |
| MYO18B | SEZ6L | ENSP00000334563 | ENSP00000248933 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.905 |
| RTN1 | BACE2 | ENSP00000267484 | ENSP00000332979 | Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 | 0.616 |
| RTN1 | SEZ6L | ENSP00000267484 | ENSP00000248933 | Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.557 |
