| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PEX1 | PEX10 | ENSP00000248633 | ENSP00000288774 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | 0.991 |
| PEX1 | PEX12 | ENSP00000248633 | ENSP00000482609 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | 0.993 |
| PEX1 | PEX13 | ENSP00000248633 | ENSP00000295030 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | 0.993 |
| PEX1 | PEX14 | ENSP00000248633 | ENSP00000349016 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins | 0.985 |
| PEX1 | PEX2 | ENSP00000248633 | ENSP00000349543 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family | 0.988 |
| PEX1 | PEX26 | ENSP00000248633 | ENSP00000331106 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins | 0.988 |
| PEX1 | PEX6 | ENSP00000248633 | ENSP00000303511 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.982 |
| PEX1 | PEX7 | ENSP00000248633 | ENSP00000315680 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family | 0.987 |
| PEX1 | UBE2D2 | ENSP00000248633 | ENSP00000381717 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of [...] | 0.954 |
| PEX1 | ZFAND6 | ENSP00000248633 | ENSP00000261749 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | AN1-type zinc finger protein 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of ’Lys-48’- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity); Zinc fingers AN1-type | 0.945 |
| PEX10 | PEX1 | ENSP00000288774 | ENSP00000248633 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.991 |
| PEX10 | PEX12 | ENSP00000288774 | ENSP00000482609 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | 0.999 |
| PEX10 | PEX13 | ENSP00000288774 | ENSP00000295030 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | 0.996 |
| PEX10 | PEX14 | ENSP00000288774 | ENSP00000349016 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins | 0.992 |
| PEX10 | PEX2 | ENSP00000288774 | ENSP00000349543 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family | 0.999 |
| PEX10 | PEX26 | ENSP00000288774 | ENSP00000331106 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins | 0.980 |
| PEX10 | PEX6 | ENSP00000288774 | ENSP00000303511 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.995 |
| PEX10 | PEX7 | ENSP00000288774 | ENSP00000315680 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family | 0.996 |
| PEX10 | UBE2D2 | ENSP00000288774 | ENSP00000381717 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of [...] | 0.970 |
| PEX10 | ZFAND6 | ENSP00000288774 | ENSP00000261749 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | AN1-type zinc finger protein 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of ’Lys-48’- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity); Zinc fingers AN1-type | 0.920 |
