| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C12orf55 | FGD6 | ENSP00000431759 | ENSP00000344446 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | 0.641 |
| C12orf55 | METTL25 | ENSP00000431759 | ENSP00000248306 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | Methyltransferase-like protein 25; Putative methyltransferase | 0.644 |
| C12orf55 | NELL1 | ENSP00000431759 | ENSP00000298925 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.559 |
| C12orf55 | SYT1 | ENSP00000431759 | ENSP00000261205 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.520 |
| C12orf55 | UHMK1 | ENSP00000431759 | ENSP00000420270 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.569 |
| DAP | GAMT | ENSP00000230895 | ENSP00000403536 | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family | 0.420 |
| DAP | METTL25 | ENSP00000230895 | ENSP00000248306 | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death | Methyltransferase-like protein 25; Putative methyltransferase | 0.729 |
| FGD6 | C12orf55 | ENSP00000344446 | ENSP00000431759 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | 0.641 |
| FGD6 | METTL25 | ENSP00000344446 | ENSP00000248306 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | Methyltransferase-like protein 25; Putative methyltransferase | 0.589 |
| FGD6 | NELL1 | ENSP00000344446 | ENSP00000298925 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.602 |
| FGD6 | SYT1 | ENSP00000344446 | ENSP00000261205 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.479 |
| FGD6 | UHMK1 | ENSP00000344446 | ENSP00000420270 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.598 |
| GAMT | DAP | ENSP00000403536 | ENSP00000230895 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death | 0.420 |
| GAMT | METTL25 | ENSP00000403536 | ENSP00000248306 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family | Methyltransferase-like protein 25; Putative methyltransferase | 0.776 |
| METTL25 | C12orf55 | ENSP00000248306 | ENSP00000431759 | Methyltransferase-like protein 25; Putative methyltransferase | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | 0.644 |
| METTL25 | DAP | ENSP00000248306 | ENSP00000230895 | Methyltransferase-like protein 25; Putative methyltransferase | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death | 0.729 |
| METTL25 | FGD6 | ENSP00000248306 | ENSP00000344446 | Methyltransferase-like protein 25; Putative methyltransferase | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | 0.589 |
| METTL25 | GAMT | ENSP00000248306 | ENSP00000403536 | Methyltransferase-like protein 25; Putative methyltransferase | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family | 0.776 |
| METTL25 | NELL1 | ENSP00000248306 | ENSP00000298925 | Methyltransferase-like protein 25; Putative methyltransferase | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.557 |
| METTL25 | ORAOV1 | ENSP00000248306 | ENSP00000279147 | Methyltransferase-like protein 25; Putative methyltransferase | Oral cancer overexpressed 1 | 0.547 |
