ABHD8 protein (human) - STRING database

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ABHD8

Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily (439 aa)

Predicted Functional Partners:

ABHD2

0.727

ANKLE1

0.723

BABAM1

0.675

TPST2

0.625

MTMR4

0.625

FIBIN

0.619

HADHA

0.616

ABHD16B

0.609

ACSL1

0.597

ABHD13

0.593

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD13	ABHD16B	ENSP00000365063	ENSP00000358932	Protein ABHD13; Abhydrolase domain containing 13	Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family	0.661
ABHD13	ABHD2	ENSP00000365063	ENSP00000268129	Protein ABHD13; Abhydrolase domain containing 13	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	0.476
ABHD13	ABHD8	ENSP00000365063	ENSP00000247706	Protein ABHD13; Abhydrolase domain containing 13	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	0.593
ABHD13	HADHA	ENSP00000365063	ENSP00000370023	Protein ABHD13; Abhydrolase domain containing 13	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.484
ABHD16B	ABHD13	ENSP00000358932	ENSP00000365063	Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family	Protein ABHD13; Abhydrolase domain containing 13	0.661
ABHD16B	ABHD2	ENSP00000358932	ENSP00000268129	Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	0.400
ABHD16B	ABHD8	ENSP00000358932	ENSP00000247706	Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	0.609
ABHD2	ABHD13	ENSP00000268129	ENSP00000365063	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	Protein ABHD13; Abhydrolase domain containing 13	0.476
ABHD2	ABHD16B	ENSP00000268129	ENSP00000358932	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family	0.400
ABHD2	ABHD8	ENSP00000268129	ENSP00000247706	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	0.727
ABHD2	ACSL1	ENSP00000268129	ENSP00000422607	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	Long-chain-fatty-acid--CoA ligase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate; Acyl-CoA synthetase family	0.543
ABHD2	HADHA	ENSP00000268129	ENSP00000370023	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.569
ABHD8	ABHD13	ENSP00000247706	ENSP00000365063	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Protein ABHD13; Abhydrolase domain containing 13	0.593
ABHD8	ABHD16B	ENSP00000247706	ENSP00000358932	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family	0.609
ABHD8	ABHD2	ENSP00000247706	ENSP00000268129	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor- progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm acti [...]	0.727
ABHD8	ACSL1	ENSP00000247706	ENSP00000422607	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Long-chain-fatty-acid--CoA ligase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate; Acyl-CoA synthetase family	0.597
ABHD8	ANKLE1	ENSP00000247706	ENSP00000377971	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Ankyrin repeat and LEM domain-containing protein 1; Endonuclease that probably plays a role in the DNA damage response and DNA repair; Ankyrin repeat domain containing	0.723
ABHD8	BABAM1	ENSP00000247706	ENSP00000352408	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cle [...]	0.675
ABHD8	FIBIN	ENSP00000247706	ENSP00000321962	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Fin bud initiation factor homolog; Belongs to the FIBIN family	0.619
ABHD8	HADHA	ENSP00000247706	ENSP00000370023	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.616

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