| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C11orf49 | NSRP1 | ENSP00000367878 | ENSP00000247026 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | 0.536 |
| CTNNBL1 | NSRP1 | ENSP00000355050 | ENSP00000247026 | Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis; Armadillo-like helical domain containing | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | 0.764 |
| EFCAB5 | KPNA4 | ENSP00000378312 | ENSP00000334373 | EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 | Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ar [...] | 0.510 |
| EFCAB5 | NSRP1 | ENSP00000378312 | ENSP00000247026 | EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | 0.714 |
| EFCAB5 | SMC4 | ENSP00000378312 | ENSP00000349961 | EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 | Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases | 0.438 |
| EFCAB5 | TRIM59 | ENSP00000378312 | ENSP00000311219 | EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 | Tripartite motif-containing protein 59; May serve as a multifunctional regulator for innate immune signaling pathways; Ring finger proteins | 0.522 |
| ESF1 | LYAR | ENSP00000202816 | ENSP00000345917 | ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | 0.938 |
| ESF1 | NSRP1 | ENSP00000202816 | ENSP00000247026 | ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | 0.723 |
| ESF1 | PNN | ENSP00000202816 | ENSP00000216832 | ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5’CAGGTG-3’. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulatio [...] | 0.859 |
| KPNA4 | EFCAB5 | ENSP00000334373 | ENSP00000378312 | Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ar [...] | EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 | 0.510 |
| KPNA4 | NSRP1 | ENSP00000334373 | ENSP00000247026 | Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ar [...] | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | 0.634 |
| KPNA4 | SMC4 | ENSP00000334373 | ENSP00000349961 | Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ar [...] | Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases | 0.572 |
| LYAR | ESF1 | ENSP00000345917 | ENSP00000202816 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | 0.938 |
| LYAR | NSRP1 | ENSP00000345917 | ENSP00000247026 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | 0.662 |
| NSRP1 | C11orf49 | ENSP00000247026 | ENSP00000367878 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.536 |
| NSRP1 | CTNNBL1 | ENSP00000247026 | ENSP00000355050 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis; Armadillo-like helical domain containing | 0.764 |
| NSRP1 | EFCAB5 | ENSP00000247026 | ENSP00000378312 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 | 0.714 |
| NSRP1 | ESF1 | ENSP00000247026 | ENSP00000202816 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | 0.723 |
| NSRP1 | KPNA4 | ENSP00000247026 | ENSP00000334373 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ar [...] | 0.634 |
| NSRP1 | LYAR | ENSP00000247026 | ENSP00000345917 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | 0.662 |
