| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSN1S1 | CSN2 | ENSP00000246891 | ENSP00000341030 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | 0.910 |
| CSN1S1 | CSN3 | ENSP00000246891 | ENSP00000304822 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | 0.860 |
| CSN1S1 | DGAT1 | ENSP00000246891 | ENSP00000482264 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders; Belongs to the membrane-bound acyltransf [...] | 0.531 |
| CSN1S1 | LALBA | ENSP00000246891 | ENSP00000301046 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family | 0.846 |
| CSN1S1 | PAEP | ENSP00000246891 | ENSP00000417898 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa- zona pellucida binding and significantly suppresses progesterone- induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the [...] | 0.712 |
| CSN1S1 | PRL | ENSP00000246891 | ENSP00000302150 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family | 0.718 |
| CSN1S1 | PRR12 | ENSP00000246891 | ENSP00000394510 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Proline-rich protein 12; Proline rich 12 | 0.651 |
| CSN1S1 | PRRG2 | ENSP00000246891 | ENSP00000246794 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | 0.602 |
| CSN1S1 | SCAF1 | ENSP00000246891 | ENSP00000353769 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.650 |
| CSN1S1 | VCL | ENSP00000246891 | ENSP00000211998 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family | 0.670 |
| CSN2 | CSN1S1 | ENSP00000341030 | ENSP00000246891 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | 0.910 |
| CSN2 | CSN3 | ENSP00000341030 | ENSP00000304822 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | 0.929 |
| CSN2 | LALBA | ENSP00000341030 | ENSP00000301046 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family | 0.907 |
| CSN2 | PAEP | ENSP00000341030 | ENSP00000417898 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa- zona pellucida binding and significantly suppresses progesterone- induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the [...] | 0.634 |
| CSN2 | PRL | ENSP00000341030 | ENSP00000302150 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family | 0.894 |
| CSN3 | CSN1S1 | ENSP00000304822 | ENSP00000246891 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | 0.860 |
| CSN3 | CSN2 | ENSP00000304822 | ENSP00000341030 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | 0.929 |
| CSN3 | DGAT1 | ENSP00000304822 | ENSP00000482264 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders; Belongs to the membrane-bound acyltransf [...] | 0.486 |
| CSN3 | LALBA | ENSP00000304822 | ENSP00000301046 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family | 0.862 |
| CSN3 | PAEP | ENSP00000304822 | ENSP00000417898 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa- zona pellucida binding and significantly suppresses progesterone- induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the [...] | 0.635 |
