• Version:
  • 11.0 [archived version]
STRINGSTRING
PRR12 PRR12 RCN3 RCN3 BCL2L12 BCL2L12 NOSIP NOSIP SCAF1 SCAF1 PRRG2 PRRG2 LCOR LCOR YAP1 YAP1 LRRC20 LRRC20 C10orf12 C10orf12 GGCX GGCX
"PRRG2" - Transmembrane gamma-carboxyglutamic acid protein 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PRRG2Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing (202 aa)    
Predicted Functional Partners:
PRR12
Proline-rich protein 12; Proline rich 12 (2036 aa)
           
  0.857
YAP1
Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] (508 aa)
       
 
  0.844
SCAF1
Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing (1312 aa)
           
  0.808
RCN3
Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family (328 aa)
           
  0.801
GGCX
Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (758 aa)
           
  0.756
NOSIP
Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family (301 aa)
     
   
  0.698
BCL2L12
Bcl-2-like protein 12; BCL2 like 12 (334 aa)
     
   
  0.689
LRRC20
Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 (184 aa)
           
  0.679
C10orf12
Ligand-dependent corepressor; May act as transcription activator that binds DNA elements with the sequence 5’-CCCTATCGATCGATCTCTACCT-3’ (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (1247 aa)
           
  0.616
LCOR
Ligand-dependent corepressor; May act as transcription activator that binds DNA elements with the sequence 5’-CCCTATCGATCGATCTCTACCT-3’ (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (433 aa)
           
  0.614
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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