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  • 11.0 [archived version]
STRINGSTRING
MAEL MAEL NAP1L5 NAP1L5 RPF1 RPF1 PDCD2L PDCD2L GNL3L GNL3L NIP7 NIP7 DDX49 DDX49 TSR3 TSR3 PRMT3 PRMT3 BYSL BYSL RPS2 RPS2
"PDCD2L" - Programmed cell death protein 2-like in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PDCD2LProgrammed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase (358 aa)    
Predicted Functional Partners:
PRMT3
Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins; Protein arginine methyltransferases (531 aa)
     
 
  0.892
RPS2
Ribosomal protein S2 (293 aa)
     
 
  0.807
BYSL
Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family (437 aa)
     
   
  0.741
MAEL
Protein maelstrom homolog; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP- bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic [...] (434 aa)
       
 
  0.685
DDX49
Probable ATP-dependent RNA helicase DDX49; DEAD-box helicase 49; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily (483 aa)
     
        0.658
TSR3
Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis (312 aa)
     
   
  0.606
NIP7
60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family (180 aa)
     
   
  0.605
GNL3L
Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] (582 aa)
     
   
  0.600
RPF1
Ribosome production factor 1; May be required for ribosome biogenesis (349 aa)
     
        0.581
NAP1L5
Nucleosome assembly protein 1 like 5 (182 aa)
     
      0.549
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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