IGFLR1 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IGFLR1

IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2 (355 aa)

Predicted Functional Partners:

CYYR1

0.570

TUBE1

0.525

LIN37

0.517

FUZ

0.489

TMEM136

0.482

IGFBPL1

0.480

KIAA1644

0.478

ZNF226

0.450

TSPYL4

0.443

LMBR1L

0.436

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYYR1	IGFLR1	ENSP00000299340	ENSP00000246532	Cysteine and tyrosine rich 1	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	0.570
CYYR1	KIAA1644	ENSP00000299340	ENSP00000370568	Cysteine and tyrosine rich 1	Uncharacterized protein KIAA1644; KIAA1644	0.706
CYYR1	LIN37	ENSP00000299340	ENSP00000301159	Cysteine and tyrosine rich 1	Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component	0.543
FUZ	IGFLR1	ENSP00000313309	ENSP00000246532	Protein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity)	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	0.489
FUZ	TUBE1	ENSP00000313309	ENSP00000357651	Protein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity)	Tubulin epsilon 1; Tubulins	0.403
IGFBPL1	IGFLR1	ENSP00000366923	ENSP00000246532	Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	0.480
IGFLR1	CYYR1	ENSP00000246532	ENSP00000299340	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Cysteine and tyrosine rich 1	0.570
IGFLR1	FUZ	ENSP00000246532	ENSP00000313309	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Protein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity)	0.489
IGFLR1	IGFBPL1	ENSP00000246532	ENSP00000366923	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing	0.480
IGFLR1	KIAA1644	ENSP00000246532	ENSP00000370568	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Uncharacterized protein KIAA1644; KIAA1644	0.478
IGFLR1	LIN37	ENSP00000246532	ENSP00000301159	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component	0.517
IGFLR1	LMBR1L	ENSP00000246532	ENSP00000267102	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Protein LMBR1L; Probable LCN1 receptor. May mediate LCN1 endocytosis	0.436
IGFLR1	TMEM136	ENSP00000246532	ENSP00000312672	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Transmembrane protein 136; Belongs to the TMEM136 family	0.482
IGFLR1	TSPYL4	ENSP00000246532	ENSP00000410943	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Testis-specific Y-encoded-like protein 4; TSPY like 4	0.443
IGFLR1	TUBE1	ENSP00000246532	ENSP00000357651	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Tubulin epsilon 1; Tubulins	0.525
IGFLR1	ZNF226	ENSP00000246532	ENSP00000465121	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	Zinc finger protein 226; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.450
KIAA1644	CYYR1	ENSP00000370568	ENSP00000299340	Uncharacterized protein KIAA1644; KIAA1644	Cysteine and tyrosine rich 1	0.706
KIAA1644	IGFLR1	ENSP00000370568	ENSP00000246532	Uncharacterized protein KIAA1644; KIAA1644	IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2	0.478
KIAA1644	TSPYL4	ENSP00000370568	ENSP00000410943	Uncharacterized protein KIAA1644; KIAA1644	Testis-specific Y-encoded-like protein 4; TSPY like 4	0.579
KIAA1644	ZNF226	ENSP00000370568	ENSP00000465121	Uncharacterized protein KIAA1644; KIAA1644	Zinc finger protein 226; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.548

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About