| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENC1 | GPR85 | ENSP00000479101 | ENSP00000297146 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | 0.740 |
| ENC1 | PLAGL2 | ENSP00000479101 | ENSP00000246229 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | 0.594 |
| ENC1 | PTCHD3 | ENSP00000479101 | ENSP00000417658 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.716 |
| GATA5 | PLAGL2 | ENSP00000252997 | ENSP00000246229 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer; GATA zinc finger domain containing | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | 0.563 |
| GATA5 | RBBP8NL | ENSP00000252997 | ENSP00000252998 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer; GATA zinc finger domain containing | RBBP8 N-terminal-like protein; RBBP8 N-terminal like | 0.549 |
| GATA5 | TM9SF4 | ENSP00000252997 | ENSP00000381104 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer; GATA zinc finger domain containing | Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells. Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the [...] | 0.547 |
| GPR85 | ENC1 | ENSP00000297146 | ENSP00000479101 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | 0.740 |
| GPR85 | PLAGL2 | ENSP00000297146 | ENSP00000246229 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | 0.622 |
| GPR85 | PTCHD3 | ENSP00000297146 | ENSP00000417658 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | Patched domain-containing protein 3; May play a role in sperm development or sperm function | 0.674 |
| IGF2 | PLAGL2 | ENSP00000391826 | ENSP00000246229 | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable) | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | 0.513 |
| KIF3B | PLAGL2 | ENSP00000364864 | ENSP00000246229 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | 0.654 |
| KIF3B | POFUT1 | ENSP00000364864 | ENSP00000364902 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | 0.535 |
| KIF3B | TM9SF4 | ENSP00000364864 | ENSP00000381104 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells. Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the [...] | 0.454 |
| MPL | PLAGL2 | ENSP00000361548 | ENSP00000246229 | Thrombopoietin receptor; Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses; Belongs to the type I cytokine receptor family. Type 1 subfamily | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | 0.651 |
| PLAGL2 | ENC1 | ENSP00000246229 | ENSP00000479101 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | 0.594 |
| PLAGL2 | GATA5 | ENSP00000246229 | ENSP00000252997 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer; GATA zinc finger domain containing | 0.563 |
| PLAGL2 | GPR85 | ENSP00000246229 | ENSP00000297146 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family | 0.622 |
| PLAGL2 | IGF2 | ENSP00000246229 | ENSP00000391826 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable) | 0.513 |
| PLAGL2 | KIF3B | ENSP00000246229 | ENSP00000364864 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | 0.654 |
| PLAGL2 | MPL | ENSP00000246229 | ENSP00000361548 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type | Thrombopoietin receptor; Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses; Belongs to the type I cytokine receptor family. Type 1 subfamily | 0.651 |
