PITHD1 protein (human) - STRING database

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PITHD1

PITH domain containing 1 (211 aa)

Predicted Functional Partners:

YWHAB

0.864

SLK

0.860

CEP85

0.665

LRRC47

0.665

NECAP2

0.627

DNAJC11

0.618

LYPLA2

0.608

SLC25A33

0.607

LUZP1

0.593

DNAJC16

0.566

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP85	DNAJC11	ENSP00000252992	ENSP00000366800	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	0.644
CEP85	DNAJC16	ENSP00000252992	ENSP00000365007	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	DnaJ heat shock protein family member C16	0.656
CEP85	LRRC47	ENSP00000252992	ENSP00000367498	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47	0.713
CEP85	LUZP1	ENSP00000252992	ENSP00000303758	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Leucine zipper protein 1	0.607
CEP85	LYPLA2	ENSP00000252992	ENSP00000363638	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity)	0.584
CEP85	NECAP2	ENSP00000252992	ENSP00000391942	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Adaptin ear-binding coat-associated protein 2; Involved in endocytosis	0.698
CEP85	PITHD1	ENSP00000252992	ENSP00000246151	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	PITH domain containing 1	0.665
CEP85	SLC25A33	ENSP00000252992	ENSP00000306328	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5’-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and [...]	0.625
DNAJC11	CEP85	ENSP00000366800	ENSP00000252992	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	0.644
DNAJC11	LRRC47	ENSP00000366800	ENSP00000367498	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47	0.619
DNAJC11	LUZP1	ENSP00000366800	ENSP00000303758	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	Leucine zipper protein 1	0.550
DNAJC11	LYPLA2	ENSP00000366800	ENSP00000363638	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity)	0.526
DNAJC11	NECAP2	ENSP00000366800	ENSP00000391942	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	Adaptin ear-binding coat-associated protein 2; Involved in endocytosis	0.586
DNAJC11	PITHD1	ENSP00000366800	ENSP00000246151	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	PITH domain containing 1	0.618
DNAJC11	SLC25A33	ENSP00000366800	ENSP00000306328	DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family	Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5’-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and [...]	0.573
DNAJC16	CEP85	ENSP00000365007	ENSP00000252992	DnaJ heat shock protein family member C16	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	0.656
DNAJC16	LRRC47	ENSP00000365007	ENSP00000367498	DnaJ heat shock protein family member C16	Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47	0.574
DNAJC16	LUZP1	ENSP00000365007	ENSP00000303758	DnaJ heat shock protein family member C16	Leucine zipper protein 1	0.522
DNAJC16	LYPLA2	ENSP00000365007	ENSP00000363638	DnaJ heat shock protein family member C16	Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity)	0.440
DNAJC16	NECAP2	ENSP00000365007	ENSP00000391942	DnaJ heat shock protein family member C16	Adaptin ear-binding coat-associated protein 2; Involved in endocytosis	0.560

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