TLE6 protein (human) - STRING database

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TLE6

Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family (572 aa)

Predicted Functional Partners:

OOEP

0.879

KHDC3L

0.812

NLRP5

0.766

HLF

0.711

PADI6

0.707

USHBP1

0.674

ANXA8

0.646

SRPX2

0.646

SYBU

0.642

AES

0.641

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AES	ANXA8	ENSP00000221561	ENSP00000478026	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	Annexin A8; Annexins	0.648
AES	HLF	ENSP00000221561	ENSP00000226067	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily	0.712
AES	SRPX2	ENSP00000221561	ENSP00000362095	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	Sushi repeat-containing protein SRPX2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development; Sushi domain containing	0.648
AES	TLE6	ENSP00000221561	ENSP00000246112	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family	0.641
ANXA8	AES	ENSP00000478026	ENSP00000221561	Annexin A8; Annexins	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	0.648
ANXA8	HLF	ENSP00000478026	ENSP00000226067	Annexin A8; Annexins	Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily	0.741
ANXA8	SRPX2	ENSP00000478026	ENSP00000362095	Annexin A8; Annexins	Sushi repeat-containing protein SRPX2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development; Sushi domain containing	0.805
ANXA8	TLE6	ENSP00000478026	ENSP00000246112	Annexin A8; Annexins	Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family	0.646
HLF	AES	ENSP00000226067	ENSP00000221561	Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily	Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family	0.712
HLF	ANXA8	ENSP00000226067	ENSP00000478026	Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily	Annexin A8; Annexins	0.741
HLF	SRPX2	ENSP00000226067	ENSP00000362095	Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily	Sushi repeat-containing protein SRPX2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development; Sushi domain containing	0.742
HLF	TLE6	ENSP00000226067	ENSP00000246112	Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily	Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family	0.711
KHDC3L	NLRP5	ENSP00000359392	ENSP00000375063	KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family	NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the NLRP family	0.745
KHDC3L	OOEP	ENSP00000359392	ENSP00000359384	KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family	Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family	0.472
KHDC3L	PADI6	ENSP00000359392	ENSP00000483125	KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family	Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo	0.589
KHDC3L	TLE6	ENSP00000359392	ENSP00000246112	KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family	Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family	0.812
NLRP5	KHDC3L	ENSP00000375063	ENSP00000359392	NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the NLRP family	KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family	0.745
NLRP5	OOEP	ENSP00000375063	ENSP00000359384	NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the NLRP family	Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family	0.805
NLRP5	PADI6	ENSP00000375063	ENSP00000483125	NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the NLRP family	Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo	0.657
NLRP5	TLE6	ENSP00000375063	ENSP00000246112	NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the NLRP family	Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the WD repeat Groucho/TLE family	0.766

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