| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD29 | SCRT2 | ENSP00000468354 | ENSP00000246104 | Ankyrin repeat domain-containing protein 29; Ankyrin repeat domain containing | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.410 |
| DLL3 | HES6 | ENSP00000205143 | ENSP00000272937 | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity) | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity); Basic helix-loop-helix proteins | 0.504 |
| DLL3 | NEUROG2 | ENSP00000205143 | ENSP00000317333 | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity) | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.562 |
| DLL3 | SCRT2 | ENSP00000205143 | ENSP00000246104 | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity) | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.543 |
| GMEB1 | SCRT2 | ENSP00000294409 | ENSP00000246104 | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.480 |
| HES6 | DLL3 | ENSP00000272937 | ENSP00000205143 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity); Basic helix-loop-helix proteins | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity) | 0.504 |
| HES6 | NEUROD1 | ENSP00000272937 | ENSP00000295108 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity); Basic helix-loop-helix proteins | Neurogenic differentiation factor 1; Acts as a transcriptional activator- mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5’-CANNTG-3’. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | 0.459 |
| HES6 | NEUROG2 | ENSP00000272937 | ENSP00000317333 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity); Basic helix-loop-helix proteins | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.494 |
| HES6 | SCRT2 | ENSP00000272937 | ENSP00000246104 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity); Basic helix-loop-helix proteins | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.458 |
| KIAA1107 | SCRT2 | ENSP00000359404 | ENSP00000246104 | Uncharacterized protein KIAA1107; KIAA1107 | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.421 |
| N4BP3 | SCRT2 | ENSP00000274605 | ENSP00000246104 | NEDD4-binding protein 3; Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage; Belongs to the N4BP3 family | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.480 |
| NEUROD1 | HES6 | ENSP00000295108 | ENSP00000272937 | Neurogenic differentiation factor 1; Acts as a transcriptional activator- mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5’-CANNTG-3’. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity); Basic helix-loop-helix proteins | 0.459 |
| NEUROD1 | SCRT2 | ENSP00000295108 | ENSP00000246104 | Neurogenic differentiation factor 1; Acts as a transcriptional activator- mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5’-CANNTG-3’. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.407 |
| NEUROG2 | DLL3 | ENSP00000317333 | ENSP00000205143 | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity) | 0.562 |
| NEUROG2 | HES6 | ENSP00000317333 | ENSP00000272937 | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity); Basic helix-loop-helix proteins | 0.494 |
| NEUROG2 | SCRT2 | ENSP00000317333 | ENSP00000246104 | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.420 |
| OLIG3 | SCRT2 | ENSP00000356708 | ENSP00000246104 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Basic helix-loop-helix proteins | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.449 |
| PDGFC | SCRT2 | ENSP00000422464 | ENSP00000246104 | Platelet-derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | 0.415 |
| SCRT2 | ANKRD29 | ENSP00000246104 | ENSP00000468354 | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | Ankyrin repeat domain-containing protein 29; Ankyrin repeat domain containing | 0.410 |
| SCRT2 | DLL3 | ENSP00000246104 | ENSP00000205143 | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity) | 0.543 |
