| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC7 | FAM198A | ENSP00000245543 | ENSP00000407301 | Armadillo repeat containing 7 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.622 |
| ARMC7 | KLHDC4 | ENSP00000245543 | ENSP00000270583 | Armadillo repeat containing 7 | Kelch domain containing 4 | 0.603 |
| ARMC7 | MAEA | ENSP00000245543 | ENSP00000302830 | Armadillo repeat containing 7 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 0.616 |
| ARMC7 | MRPL41 | ENSP00000245543 | ENSP00000360498 | Armadillo repeat containing 7 | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | 0.733 |
| ARMC7 | NALCN | ENSP00000245543 | ENSP00000251127 | Armadillo repeat containing 7 | Sodium leak channel non-selective protein; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability. Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by contro [...] | 0.661 |
| ARMC7 | NUP85 | ENSP00000245543 | ENSP00000245544 | Armadillo repeat containing 7 | Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade; Nucl [...] | 0.739 |
| ARMC7 | RBM48 | ENSP00000245543 | ENSP00000265732 | Armadillo repeat containing 7 | RNA-binding protein 48; RNA binding motif containing | 0.692 |
| ARMC7 | TMEM261 | ENSP00000245543 | ENSP00000350961 | Armadillo repeat containing 7 | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I | 0.620 |
| ARMC7 | TUSC5 | ENSP00000245543 | ENSP00000329548 | Armadillo repeat containing 7 | Tumor suppressor candidate 5; May be involved in fat metabolism; Belongs to the CD225/Dispanin family | 0.696 |
| ARMC7 | ZNF662 | ENSP00000245543 | ENSP00000329264 | Armadillo repeat containing 7 | Zinc finger protein 662; Zinc fingers C2H2-type | 0.650 |
| FAM198A | ARMC7 | ENSP00000407301 | ENSP00000245543 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Armadillo repeat containing 7 | 0.622 |
| FAM198A | ZNF662 | ENSP00000407301 | ENSP00000329264 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Zinc finger protein 662; Zinc fingers C2H2-type | 0.663 |
| KLHDC4 | ARMC7 | ENSP00000270583 | ENSP00000245543 | Kelch domain containing 4 | Armadillo repeat containing 7 | 0.603 |
| KLHDC4 | TMEM261 | ENSP00000270583 | ENSP00000350961 | Kelch domain containing 4 | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I | 0.609 |
| MAEA | ARMC7 | ENSP00000302830 | ENSP00000245543 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | Armadillo repeat containing 7 | 0.616 |
| MAEA | MRPL41 | ENSP00000302830 | ENSP00000360498 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | 0.414 |
| MRPL41 | ARMC7 | ENSP00000360498 | ENSP00000245543 | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | Armadillo repeat containing 7 | 0.733 |
| MRPL41 | MAEA | ENSP00000360498 | ENSP00000302830 | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 0.414 |
| NALCN | ARMC7 | ENSP00000251127 | ENSP00000245543 | Sodium leak channel non-selective protein; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability. Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by contro [...] | Armadillo repeat containing 7 | 0.661 |
| NUP85 | ARMC7 | ENSP00000245544 | ENSP00000245543 | Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade; Nucl [...] | Armadillo repeat containing 7 | 0.739 |
