• Version:
  • 11.0 [archived version]
STRINGSTRING
RHOA RHOA MYL9 MYL9 MYL6B MYL6B ACTR2 ACTR2 MYH2 MYH2 MYL5 MYL5 MYL3 MYL3 TPM1 TPM1 MYH1 MYH1 MYL1 MYL1 MYLPF MYLPF
"MYH2" - Myosin-2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MYH2Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity); Myosin heavy chains (1941 aa)    
Predicted Functional Partners:
MYL1
Myosin light chain 1/3, skeletal muscle isoform; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing (194 aa)
     
  0.967
MYH1
Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1939 aa)
     
 
0.958
MYLPF
Myosin light chain, phosphorylatable, fast skeletal muscle; EF-hand domain containing (169 aa)
     
  0.956
MYL3
Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing (195 aa)
     
  0.947
MYL6B
Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing (208 aa)
       
  0.945
MYL5
Myosin light chain 5; EF-hand domain containing (173 aa)
       
  0.944
RHOA
Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated r [...] (193 aa)
     
  0.941
MYL9
Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion; EF-hand domain containing (172 aa)
       
  0.938
ACTR2
Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (399 aa)
     
  0.930
TPM1
Tropomyosin alpha-1 chain; Tropomyosin 1; Tropomyosins (284 aa)
     
 
  0.929
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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