EMC3 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Score

EMC3

ER membrane protein complex subunit 3 (261 aa)

Predicted Functional Partners:

EMC2

0.999

EMC4

0.999

EMC1

0.999

EMC8

0.999

EMC9

0.999

EMC10

0.997

EMC7

0.996

MMGT1

0.994

EMC6

0.989

DERL2

0.934

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DERL2	EMC1	ENSP00000158771	ENSP00000420608	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	ER membrane protein complex subunit 1; Belongs to the EMC1 family	0.908
DERL2	EMC2	ENSP00000158771	ENSP00000220853	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing	0.924
DERL2	EMC3	ENSP00000158771	ENSP00000245046	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	ER membrane protein complex subunit 3	0.934
EMC1	DERL2	ENSP00000420608	ENSP00000158771	ER membrane protein complex subunit 1; Belongs to the EMC1 family	Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]	0.908
EMC1	EMC10	ENSP00000420608	ENSP00000334037	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 10; Belongs to the EMC10 family	0.971
EMC1	EMC2	ENSP00000420608	ENSP00000220853	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing	0.999
EMC1	EMC3	ENSP00000420608	ENSP00000245046	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 3	0.999
EMC1	EMC4	ENSP00000420608	ENSP00000267750	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 4; May mediate anti-apoptotic activity	0.999
EMC1	EMC6	ENSP00000420608	ENSP00000380322	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 6; Belongs to the EMC6 family	0.989
EMC1	EMC7	ENSP00000420608	ENSP00000256545	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 7	0.995
EMC1	EMC8	ENSP00000420608	ENSP00000253457	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 8	0.998
EMC1	EMC9	ENSP00000420608	ENSP00000403210	ER membrane protein complex subunit 1; Belongs to the EMC1 family	ER membrane protein complex subunit 9	0.999
EMC1	MMGT1	ENSP00000420608	ENSP00000306220	ER membrane protein complex subunit 1; Belongs to the EMC1 family	Membrane magnesium transporter 1; Mediates Mg(2+) transport; Belongs to the membrane magnesium transporter (TC 1.A.67) family	0.994
EMC10	EMC1	ENSP00000334037	ENSP00000420608	ER membrane protein complex subunit 10; Belongs to the EMC10 family	ER membrane protein complex subunit 1; Belongs to the EMC1 family	0.971
EMC10	EMC2	ENSP00000334037	ENSP00000220853	ER membrane protein complex subunit 10; Belongs to the EMC10 family	ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing	0.994
EMC10	EMC3	ENSP00000334037	ENSP00000245046	ER membrane protein complex subunit 10; Belongs to the EMC10 family	ER membrane protein complex subunit 3	0.997
EMC10	EMC4	ENSP00000334037	ENSP00000267750	ER membrane protein complex subunit 10; Belongs to the EMC10 family	ER membrane protein complex subunit 4; May mediate anti-apoptotic activity	0.968
EMC10	EMC6	ENSP00000334037	ENSP00000380322	ER membrane protein complex subunit 10; Belongs to the EMC10 family	ER membrane protein complex subunit 6; Belongs to the EMC6 family	0.980
EMC10	EMC7	ENSP00000334037	ENSP00000256545	ER membrane protein complex subunit 10; Belongs to the EMC10 family	ER membrane protein complex subunit 7	0.997
EMC10	EMC8	ENSP00000334037	ENSP00000253457	ER membrane protein complex subunit 10; Belongs to the EMC10 family	ER membrane protein complex subunit 8	0.997

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