• Version:
  • 11.0 [archived version]
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DTWD2 DTWD2 SLC4A5 SLC4A5 SERINC1 SERINC1 SLC4A4 SLC4A4 CNOT6L CNOT6L UNC5CL UNC5CL PGAM1 PGAM1 PLCE1 PLCE1 NFYA NFYA SLC52A3 SLC52A3 CLMN CLMN
"UNC5CL" - UNC5C-like protein in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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UNC5CLUNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family (518 aa)    
Predicted Functional Partners:
PGAM1
Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity (254 aa)
       
      0.548
SLC4A4
Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+)-HCO3(-) stoichiometry varying from 1-2 to 1-3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family (1094 aa)
           
  0.544
SLC4A5
Electrogenic sodium bicarbonate cotransporter 4; Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+)-HCO3(-) stoichiometry of 2-1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+)-HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH; Solute carriers (1137 aa)
           
  0.530
NFYA
Nuclear transcription factor Y subunit alpha; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5’- CCAAT-3’ box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 (347 aa)
           
  0.514
CNOT6L
CCR4-NOT transcription complex subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3’ [...] (555 aa)
           
  0.508
SERINC1
Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family (453 aa)
           
  0.504
PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases (2302 aa)
     
   
  0.482
DTWD2
DTW domain containing 2 (298 aa)
           
  0.480
CLMN
Calmin (1002 aa)
           
  0.478
SLC52A3
Solute carrier family 52, riboflavin transporter, member 3; Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption. Riboflavin transport is Na(+)- independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), by methylene blue, and to a lesser extent by amiloride; Solute carriers (469 aa)
           
  0.474
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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