node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLMN | UNC5CL | ENSP00000298912 | ENSP00000244565 | Calmin | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.478 |
CNOT6L | SERINC1 | ENSP00000424896 | ENSP00000342962 | CCR4-NOT transcription complex subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3’ [...] | Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family | 0.577 |
CNOT6L | UNC5CL | ENSP00000424896 | ENSP00000244565 | CCR4-NOT transcription complex subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3’ [...] | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.508 |
DTWD2 | SERINC1 | ENSP00000425048 | ENSP00000342962 | DTW domain containing 2 | Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family | 0.694 |
DTWD2 | UNC5CL | ENSP00000425048 | ENSP00000244565 | DTW domain containing 2 | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.480 |
NFYA | UNC5CL | ENSP00000345702 | ENSP00000244565 | Nuclear transcription factor Y subunit alpha; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5’- CCAAT-3’ box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.514 |
PGAM1 | UNC5CL | ENSP00000359991 | ENSP00000244565 | Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.548 |
PLCE1 | SLC52A3 | ENSP00000360431 | ENSP00000217254 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases | Solute carrier family 52, riboflavin transporter, member 3; Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption. Riboflavin transport is Na(+)- independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), by methylene blue, and to a lesser extent by amiloride; Solute carriers | 0.668 |
PLCE1 | UNC5CL | ENSP00000360431 | ENSP00000244565 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.482 |
SERINC1 | CNOT6L | ENSP00000342962 | ENSP00000424896 | Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family | CCR4-NOT transcription complex subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3’ [...] | 0.577 |
SERINC1 | DTWD2 | ENSP00000342962 | ENSP00000425048 | Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family | DTW domain containing 2 | 0.694 |
SERINC1 | UNC5CL | ENSP00000342962 | ENSP00000244565 | Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.504 |
SLC4A4 | UNC5CL | ENSP00000393557 | ENSP00000244565 | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+)-HCO3(-) stoichiometry varying from 1-2 to 1-3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.544 |
SLC4A5 | UNC5CL | ENSP00000251768 | ENSP00000244565 | Electrogenic sodium bicarbonate cotransporter 4; Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+)-HCO3(-) stoichiometry of 2-1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+)-HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH; Solute carriers | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.530 |
SLC52A3 | PLCE1 | ENSP00000217254 | ENSP00000360431 | Solute carrier family 52, riboflavin transporter, member 3; Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption. Riboflavin transport is Na(+)- independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), by methylene blue, and to a lesser extent by amiloride; Solute carriers | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation; C2 domain containing phospholipases | 0.668 |
SLC52A3 | UNC5CL | ENSP00000217254 | ENSP00000244565 | Solute carrier family 52, riboflavin transporter, member 3; Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption. Riboflavin transport is Na(+)- independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), by methylene blue, and to a lesser extent by amiloride; Solute carriers | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | 0.474 |
UNC5CL | CLMN | ENSP00000244565 | ENSP00000298912 | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | Calmin | 0.478 |
UNC5CL | CNOT6L | ENSP00000244565 | ENSP00000424896 | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | CCR4-NOT transcription complex subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3’ [...] | 0.508 |
UNC5CL | DTWD2 | ENSP00000244565 | ENSP00000425048 | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | DTW domain containing 2 | 0.480 |
UNC5CL | NFYA | ENSP00000244565 | ENSP00000345702 | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family | Nuclear transcription factor Y subunit alpha; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5’- CCAAT-3’ box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 | 0.514 |