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  • 11.0 [archived version]
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FABP3 FABP3 PLIN2 PLIN2 AGPAT6 AGPAT6 XDH XDH IPP IPP MOSPD2 MOSPD2 BTN1A1 BTN1A1 PRDM5 PRDM5 PPL PPL CSN2 CSN2 FLNB FLNB
"BTN1A1" - Butyrophilin subfamily 1 member A1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BTN1A1Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family (526 aa)    
Predicted Functional Partners:
XDH
Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) (1333 aa)
     
  0.975
PPL
Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family (1756 aa)
       
  0.946
PRDM5
PR domain zinc finger protein 5; Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. Ma [...] (630 aa)
           
  0.572
PLIN2
Perilipin-2; May be involved in development and maintenance of adipose tissue; Perilipins (437 aa)
           
  0.554
MOSPD2
Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines (518 aa)
       
      0.524
CSN2
Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family (226 aa)
     
   
  0.514
FLNB
Filamin-B; Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro; Belongs to the filamin family (2633 aa)
           
  0.509
AGPAT6
Glycerol-3-phosphate acyltransferase 4; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs (456 aa)
     
   
  0.502
IPP
Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton; BTB domain containing (584 aa)
     
   
  0.493
FABP3
Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family (133 aa)
           
  0.488
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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