| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHSA1 | IRGC | ENSP00000216479 | ENSP00000244314 | Activator of 90 kDa heat shock protein ATPase homolog 1; Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.620 |
| ATG16L1 | IRGC | ENSP00000375872 | ENSP00000244314 | Autophagy-related protein 16-1; Plays an essential role in autophagy- interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2- driven inflammatory cytokine response. Plays a role in regulating morphology and function of Paneth cell; Belongs to the W [...] | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.521 |
| CXCL11 | IRGC | ENSP00000306884 | ENSP00000244314 | C-X-C motif chemokine 11; Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses; Belongs to the intercrine alpha (chemokine CxC) family | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.440 |
| DCTN4 | IRGC | ENSP00000414906 | ENSP00000244314 | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.598 |
| IRGC | AHSA1 | ENSP00000244314 | ENSP00000216479 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Activator of 90 kDa heat shock protein ATPase homolog 1; Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins | 0.620 |
| IRGC | ATG16L1 | ENSP00000244314 | ENSP00000375872 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Autophagy-related protein 16-1; Plays an essential role in autophagy- interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2- driven inflammatory cytokine response. Plays a role in regulating morphology and function of Paneth cell; Belongs to the W [...] | 0.521 |
| IRGC | CXCL11 | ENSP00000244314 | ENSP00000306884 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | C-X-C motif chemokine 11; Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses; Belongs to the intercrine alpha (chemokine CxC) family | 0.440 |
| IRGC | DCTN4 | ENSP00000244314 | ENSP00000414906 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.598 |
| IRGC | ITLN2 | ENSP00000244314 | ENSP00000357008 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | 0.470 |
| IRGC | PLEKHB1 | ENSP00000244314 | ENSP00000346127 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.506 |
| IRGC | SPZ1 | ENSP00000244314 | ENSP00000369611 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5’- CANNTG-3’(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity); Protein phosphatase 1 regulatory subunits | 0.448 |
| IRGC | TENM3 | ENSP00000244314 | ENSP00000424226 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Teneurin-3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity) | 0.565 |
| IRGC | TNNI3K | ENSP00000244314 | ENSP00000322251 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | 0.450 |
| IRGC | TSACC | ENSP00000244314 | ENSP00000357238 | Interferon-inducible GTPase 5; Immunity related GTPase cinema | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family | 0.442 |
| ITLN2 | IRGC | ENSP00000357008 | ENSP00000244314 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.470 |
| PLEKHB1 | IRGC | ENSP00000346127 | ENSP00000244314 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.506 |
| PLEKHB1 | TENM3 | ENSP00000346127 | ENSP00000424226 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Teneurin-3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity) | 0.512 |
| SPZ1 | IRGC | ENSP00000369611 | ENSP00000244314 | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5’- CANNTG-3’(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity); Protein phosphatase 1 regulatory subunits | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.448 |
| TENM3 | IRGC | ENSP00000424226 | ENSP00000244314 | Teneurin-3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity) | Interferon-inducible GTPase 5; Immunity related GTPase cinema | 0.565 |
| TENM3 | PLEKHB1 | ENSP00000424226 | ENSP00000346127 | Teneurin-3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity) | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.512 |
