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STRINGSTRING
SH3PXD2B SH3PXD2B SSX4B SSX4B MAGEA10 MAGEA10 SSX4 SSX4 CTAG1A CTAG1A MAGEC2 MAGEC2 MAGEA4 MAGEA4 PASD1 PASD1 CTAG2 CTAG2 CTAG1B CTAG1B SSX2 SSX2
"MAGEA10" - Melanoma-associated antigen 10 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAGEA10Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family (369 aa)    
Predicted Functional Partners:
PASD1
Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed (773 aa)
      
   
  0.873
CTAG1A
Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family (180 aa)
            
  0.735
CTAG1B
Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family (180 aa)
            
  0.734
CTAG2
Cancer/testis antigen 2 (210 aa)
            
  0.671
SSX2
Synovial sarcoma, X breakpoint 2; SSX family member 2 (223 aa)
            
  0.669
SSX4
Synovial sarcoma, X breakpoint 4; Could act as a modulator of transcription (188 aa)
            
  0.648
SSX4B
Protein SSX4; Could act as a modulator of transcription (188 aa)
            
  0.645
MAGEA4
Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family (317 aa)
      
 
0.599
SH3PXD2B
SH3 and PX domain-containing protein 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) (911 aa)
        
 
  0.593
MAGEC2
Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family (373 aa)
      
   
0.580
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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