WFDC3 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

WFDC3

WAP four-disulfide core domain containing (231 aa)

Predicted Functional Partners:

DUX4L1

0.698

DUX4

0.695

DUX4L8

0.670

DUX4L7

0.670

SPINT4

0.668

WFDC13

0.641

WFDC10B

0.575

DNTTIP1

0.559

SPINT3

0.559

PRSS48

0.558

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNTTIP1	SPINT4	ENSP00000361705	ENSP00000279058	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5’- GNTGCATG-3’ following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA	Serine peptidase inhibitor, Kunitz type 4	0.571
DNTTIP1	WFDC10B	ENSP00000361705	ENSP00000337466	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5’- GNTGCATG-3’ following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA	Protein WFDC10B; WAP four-disulfide core domain containing	0.475
DNTTIP1	WFDC13	ENSP00000361705	ENSP00000302938	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5’- GNTGCATG-3’ following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA	WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing	0.553
DNTTIP1	WFDC3	ENSP00000361705	ENSP00000243938	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5’- GNTGCATG-3’ following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA	WAP four-disulfide core domain containing	0.559
DUX4	DUX4L1	ENSP00000458065	ENSP00000451207	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	0.800
DUX4	DUX4L7	ENSP00000458065	ENSP00000451411	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	0.801
DUX4	DUX4L8	ENSP00000458065	ENSP00000485452	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	0.801
DUX4	WFDC3	ENSP00000458065	ENSP00000243938	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	WAP four-disulfide core domain containing	0.695
DUX4L1	DUX4	ENSP00000451207	ENSP00000458065	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	0.800
DUX4L1	DUX4L7	ENSP00000451207	ENSP00000451411	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	0.808
DUX4L1	DUX4L8	ENSP00000451207	ENSP00000485452	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	0.815
DUX4L1	WFDC3	ENSP00000451207	ENSP00000243938	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	WAP four-disulfide core domain containing	0.698
DUX4L7	DUX4	ENSP00000451411	ENSP00000458065	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	0.801
DUX4L7	DUX4L1	ENSP00000451411	ENSP00000451207	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	0.808
DUX4L7	DUX4L8	ENSP00000451411	ENSP00000485452	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	0.814
DUX4L7	WFDC3	ENSP00000451411	ENSP00000243938	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	WAP four-disulfide core domain containing	0.670
DUX4L8	DUX4	ENSP00000485452	ENSP00000458065	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family	0.801
DUX4L8	DUX4L1	ENSP00000485452	ENSP00000451207	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes	0.815
DUX4L8	DUX4L7	ENSP00000485452	ENSP00000451411	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	0.814
DUX4L8	WFDC3	ENSP00000485452	ENSP00000243938	Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes	WAP four-disulfide core domain containing	0.670

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