• Version:
  • 11.0 [archived version]
STRINGSTRING
MURC MURC DDIAS DDIAS MMS22L MMS22L C1orf112 C1orf112 PARPBP PARPBP ENKD1 ENKD1 SMPX SMPX C1orf35 C1orf35 DAPL1 DAPL1 SERPINB11 SERPINB11 SPINK6 SPINK6
"ENKD1" - Enkurin domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENKD1Enkurin domain containing 1 (346 aa)    
Predicted Functional Partners:
C1orf35
Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 (263 aa)
           
  0.632
C1orf112
Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112 (853 aa)
     
   
  0.584
SPINK6
Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type (80 aa)
           
  0.515
DAPL1
Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis (107 aa)
           
  0.477
SERPINB11
Serpin B11; Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change; Serpin peptidase inhibitors (392 aa)
           
  0.473
PARPBP
PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect; Belongs to the PARI family (579 aa)
     
   
  0.465
DDIAS
DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival (998 aa)
           
  0.452
MURC
Caveolae-associated protein 4; Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway; Belongs to the CA [...] (364 aa)
           
  0.440
SMPX
Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Deafness associated genes (88 aa)
           
  0.440
MMS22L
Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (1243 aa)
     
   
  0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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