node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf112 | DDIAS | ENSP00000286031 | ENSP00000435421 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival | 0.416 |
C1orf112 | ENKD1 | ENSP00000286031 | ENSP00000243878 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112 | Enkurin domain containing 1 | 0.584 |
C1orf112 | PARPBP | ENSP00000286031 | ENSP00000332915 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112 | PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect; Belongs to the PARI family | 0.781 |
C1orf35 | DAPL1 | ENSP00000272139 | ENSP00000309538 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis | 0.420 |
C1orf35 | ENKD1 | ENSP00000272139 | ENSP00000243878 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Enkurin domain containing 1 | 0.632 |
C1orf35 | SERPINB11 | ENSP00000272139 | ENSP00000441497 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Serpin B11; Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change; Serpin peptidase inhibitors | 0.412 |
C1orf35 | SPINK6 | ENSP00000272139 | ENSP00000324870 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.441 |
DAPL1 | C1orf35 | ENSP00000309538 | ENSP00000272139 | Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | 0.420 |
DAPL1 | ENKD1 | ENSP00000309538 | ENSP00000243878 | Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis | Enkurin domain containing 1 | 0.477 |
DDIAS | C1orf112 | ENSP00000435421 | ENSP00000286031 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112 | 0.416 |
DDIAS | ENKD1 | ENSP00000435421 | ENSP00000243878 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival | Enkurin domain containing 1 | 0.452 |
ENKD1 | C1orf112 | ENSP00000243878 | ENSP00000286031 | Enkurin domain containing 1 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112 | 0.584 |
ENKD1 | C1orf35 | ENSP00000243878 | ENSP00000272139 | Enkurin domain containing 1 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | 0.632 |
ENKD1 | DAPL1 | ENSP00000243878 | ENSP00000309538 | Enkurin domain containing 1 | Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis | 0.477 |
ENKD1 | DDIAS | ENSP00000243878 | ENSP00000435421 | Enkurin domain containing 1 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival | 0.452 |
ENKD1 | MMS22L | ENSP00000243878 | ENSP00000275053 | Enkurin domain containing 1 | Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA | 0.439 |
ENKD1 | MURC | ENSP00000243878 | ENSP00000418668 | Enkurin domain containing 1 | Caveolae-associated protein 4; Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway; Belongs to the CA [...] | 0.440 |
ENKD1 | PARPBP | ENSP00000243878 | ENSP00000332915 | Enkurin domain containing 1 | PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect; Belongs to the PARI family | 0.465 |
ENKD1 | SERPINB11 | ENSP00000243878 | ENSP00000441497 | Enkurin domain containing 1 | Serpin B11; Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change; Serpin peptidase inhibitors | 0.473 |
ENKD1 | SMPX | ENSP00000243878 | ENSP00000368808 | Enkurin domain containing 1 | Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Deafness associated genes | 0.440 |