node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OR10V1 | ORMDL2 | ENSP00000302199 | ENSP00000243045 | Olfactory receptor 10V1; Odorant receptor; Olfactory receptors, family 10 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | 0.669 |
OR1L8 | ORMDL2 | ENSP00000306607 | ENSP00000243045 | Olfactory receptor 1L8; Odorant receptor; Olfactory receptors, family 1 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | 0.669 |
ORM1 | ORM2 | ENSP00000259396 | ENSP00000394936 | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | 0.999 |
ORM1 | ORMDL2 | ENSP00000259396 | ENSP00000243045 | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | 0.907 |
ORM1 | SPTLC2 | ENSP00000259396 | ENSP00000216484 | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family | 0.411 |
ORM2 | ORM1 | ENSP00000394936 | ENSP00000259396 | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | 0.999 |
ORM2 | ORMDL2 | ENSP00000394936 | ENSP00000243045 | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | 0.911 |
ORMDL2 | OR10V1 | ENSP00000243045 | ENSP00000302199 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Olfactory receptor 10V1; Odorant receptor; Olfactory receptors, family 10 | 0.669 |
ORMDL2 | OR1L8 | ENSP00000243045 | ENSP00000306607 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Olfactory receptor 1L8; Odorant receptor; Olfactory receptors, family 1 | 0.669 |
ORMDL2 | ORM1 | ENSP00000243045 | ENSP00000259396 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | 0.907 |
ORMDL2 | ORM2 | ENSP00000243045 | ENSP00000394936 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | 0.911 |
ORMDL2 | SPTLC1 | ENSP00000243045 | ENSP00000262554 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability t [...] | 0.876 |
ORMDL2 | SPTLC2 | ENSP00000243045 | ENSP00000216484 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family | 0.777 |
ORMDL2 | SPTLC3 | ENSP00000243045 | ENSP00000381968 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.718 |
ORMDL2 | SPTSSA | ENSP00000243045 | ENSP00000298130 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA | 0.636 |
ORMDL2 | SPTSSB | ENSP00000243045 | ENSP00000352097 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction | 0.600 |
ORMDL2 | TMEM120A | ENSP00000243045 | ENSP00000473983 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family | 0.671 |
SPTLC1 | ORMDL2 | ENSP00000262554 | ENSP00000243045 | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability t [...] | ORM1-like protein 2; Negative regulator of sphingolipid synthesis | 0.876 |
SPTLC1 | SPTLC2 | ENSP00000262554 | ENSP00000216484 | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability t [...] | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family | 0.991 |
SPTLC1 | SPTLC3 | ENSP00000262554 | ENSP00000381968 | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability t [...] | Serine palmitoyltransferase 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.990 |