GJA3 protein (human) - STRING database

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GJA3

Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily (435 aa)

Predicted Functional Partners:

CRYBB2

0.921

CRYBB1

0.857

HSPB4

0.850

CRYA1

0.850

BFSP2

0.835

MIP

0.829

CRYBA1

0.818

CRYGC

0.800

CRYBB3

0.793

CRYGS

0.772

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFSP2	CRYA1	ENSP00000304987	ENSP00000482816	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	CRYBA1	ENSP00000304987	ENSP00000225387	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	0.784
BFSP2	CRYBB1	ENSP00000304987	ENSP00000215939	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.798
BFSP2	CRYBB2	ENSP00000304987	ENSP00000381273	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.812
BFSP2	CRYBB3	ENSP00000304987	ENSP00000215855	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.719
BFSP2	CRYGC	ENSP00000304987	ENSP00000282141	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gamma-crystallin C; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.753
BFSP2	CRYGS	ENSP00000304987	ENSP00000376287	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.795
BFSP2	GJA3	ENSP00000304987	ENSP00000241125	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.835
BFSP2	HSPB4	ENSP00000304987	ENSP00000291554	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	MIP	ENSP00000304987	ENSP00000257979	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.814
CRYA1	BFSP2	ENSP00000482816	ENSP00000304987	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	0.819
CRYA1	CRYBA1	ENSP00000482816	ENSP00000225387	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	0.905
CRYA1	CRYBB1	ENSP00000482816	ENSP00000215939	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.940
CRYA1	CRYBB2	ENSP00000482816	ENSP00000381273	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.934
CRYA1	CRYBB3	ENSP00000482816	ENSP00000215855	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.876
CRYA1	CRYGC	ENSP00000482816	ENSP00000282141	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gamma-crystallin C; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.855
CRYA1	CRYGS	ENSP00000482816	ENSP00000376287	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.838
CRYA1	GJA3	ENSP00000482816	ENSP00000241125	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.850
CRYA1	MIP	ENSP00000482816	ENSP00000257979	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.716
CRYBA1	BFSP2	ENSP00000225387	ENSP00000304987	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	0.784

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