| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCD3 | PEX10 | ENSP00000359233 | ENSP00000288774 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | 0.788 |
| ABCD3 | PEX11A | ENSP00000359233 | ENSP00000300056 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisomal membrane protein 11A; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface; Peroxins | 0.742 |
| ABCD3 | PEX12 | ENSP00000359233 | ENSP00000482609 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | 0.771 |
| ABCD3 | PEX13 | ENSP00000359233 | ENSP00000295030 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | 0.879 |
| ABCD3 | PEX16 | ENSP00000359233 | ENSP00000241041 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3; Belongs to the peroxin-16 family | 0.876 |
| ABCD3 | PEX19 | ENSP00000359233 | ENSP00000357051 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53; Belongs to the peroxin-19 family | 0.991 |
| ABCD3 | PEX3 | ENSP00000359233 | ENSP00000356563 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family | 0.995 |
| ABCD3 | PEX5 | ENSP00000359233 | ENSP00000391601 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.864 |
| ABCD3 | PEX6 | ENSP00000359233 | ENSP00000303511 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.665 |
| ABCD3 | PEX7 | ENSP00000359233 | ENSP00000315680 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family | 0.683 |
| PEX10 | ABCD3 | ENSP00000288774 | ENSP00000359233 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity | 0.788 |
| PEX10 | PEX11A | ENSP00000288774 | ENSP00000300056 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal membrane protein 11A; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface; Peroxins | 0.892 |
| PEX10 | PEX12 | ENSP00000288774 | ENSP00000482609 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | 0.999 |
| PEX10 | PEX13 | ENSP00000288774 | ENSP00000295030 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | 0.996 |
| PEX10 | PEX16 | ENSP00000288774 | ENSP00000241041 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3; Belongs to the peroxin-16 family | 0.917 |
| PEX10 | PEX19 | ENSP00000288774 | ENSP00000357051 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53; Belongs to the peroxin-19 family | 0.982 |
| PEX10 | PEX3 | ENSP00000288774 | ENSP00000356563 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family | 0.941 |
| PEX10 | PEX5 | ENSP00000288774 | ENSP00000391601 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.966 |
| PEX10 | PEX6 | ENSP00000288774 | ENSP00000303511 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.995 |
| PEX10 | PEX7 | ENSP00000288774 | ENSP00000315680 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family | 0.996 |
