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KLRK1 - Killer cell lectin-like receptor subfamily K, member 1; Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination o [...]
[a.k.a. NKG2D, D12S2489E, AK292020,
KLRC4 - NKG2-F type II integral membrane protein; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells; Killer cell lectin like receptors
[a.k.a. NKG2F, HGNC:6377, OMIM:602893,
© STRING Consortium 2020
SIB - Swiss Institute of Bioinformatics
CPR - Novo Nordisk Foundation Center Protein Research
EMBL - European Molecular Biology Laboratory
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