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BRD8 BRD8 REEP2 REEP2 DYRK1B DYRK1B DCAF7 DCAF7 KDM3B KDM3B FAM53C FAM53C DYRK1A DYRK1A FAM13B FAM13B RPL26L1 RPL26L1 KBTBD2 KBTBD2 C19orf60 C19orf60
"FAM53C" - Protein FAM53C in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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FAM53CProtein FAM53C; Family with sequence similarity 53 member C (392 aa)    
Predicted Functional Partners:
DYRK1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] (763 aa)
       
      0.850
DYRK1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily (629 aa)
       
      0.808
DCAF7
DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family (342 aa)
       
      0.719
KDM3B
Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases (1761 aa)
 
       
  0.696
FAM13B
Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins (915 aa)
           
  0.575
BRD8
Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other prote [...] (1235 aa)
           
  0.556
REEP2
Receptor expression-enhancing protein 2; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity); Belongs to the DP1 family (254 aa)
     
   
  0.555
RPL26L1
Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family (145 aa)
           
  0.537
C19orf60
Uncharacterized protein C19orf60; Chromosome 19 open reading frame 60 (201 aa)
           
  0.532
KBTBD2
Kelch repeat and BTB domain containing 2 (623 aa)
     
   
  0.529
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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