CCDC77 protein (human) - STRING database

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CCDC77

Coiled-coil domain containing 77 (488 aa)

Predicted Functional Partners:

AURKAIP1

0.727

CCDC124

0.718

OFD1

0.692

TUBGCP2

0.680

CDKN3

0.670

CEP135

0.633

SASH3

0.597

CEP104

0.592

CEP162

0.540

PPP2R3C

0.532

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AURKAIP1	CCDC124	ENSP00000342676	ENSP00000471455	Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	0.739
AURKAIP1	CCDC77	ENSP00000342676	ENSP00000239830	Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation	Coiled-coil domain containing 77	0.727
AURKAIP1	CDKN3	ENSP00000342676	ENSP00000335357	Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation	Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at ’Thr-160’ in a cyclin-dependent manner; CDC14 phosphatases	0.653
AURKAIP1	TUBGCP2	ENSP00000342676	ENSP00000446093	Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation	Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.645
CCDC124	AURKAIP1	ENSP00000471455	ENSP00000342676	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation	0.739
CCDC124	CCDC77	ENSP00000471455	ENSP00000239830	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	Coiled-coil domain containing 77	0.718
CCDC124	CDKN3	ENSP00000471455	ENSP00000335357	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at ’Thr-160’ in a cyclin-dependent manner; CDC14 phosphatases	0.568
CCDC124	TUBGCP2	ENSP00000471455	ENSP00000446093	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.629
CCDC77	AURKAIP1	ENSP00000239830	ENSP00000342676	Coiled-coil domain containing 77	Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation	0.727
CCDC77	CCDC124	ENSP00000239830	ENSP00000471455	Coiled-coil domain containing 77	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	0.718
CCDC77	CDKN3	ENSP00000239830	ENSP00000335357	Coiled-coil domain containing 77	Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at ’Thr-160’ in a cyclin-dependent manner; CDC14 phosphatases	0.670
CCDC77	CEP104	ENSP00000239830	ENSP00000367476	Coiled-coil domain containing 77	Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip	0.592
CCDC77	CEP135	ENSP00000239830	ENSP00000257287	Coiled-coil domain containing 77	Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole; Belongs to the CEP135/TSGA10 family	0.633
CCDC77	CEP162	ENSP00000239830	ENSP00000385215	Coiled-coil domain containing 77	Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules; Belongs to the CEP162 family	0.540
CCDC77	OFD1	ENSP00000239830	ENSP00000344314	Coiled-coil domain containing 77	Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...]	0.692
CCDC77	PPP2R3C	ENSP00000239830	ENSP00000261475	Coiled-coil domain containing 77	Serine/threonine-protein phosphatase 2A regulatory subunit B’’ subunit gamma; May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells; Protein phosphatase 2 regulatory subunits	0.532
CCDC77	SASH3	ENSP00000239830	ENSP00000349359	Coiled-coil domain containing 77	SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes; SAM and SH3 domain containing	0.597
CCDC77	TUBGCP2	ENSP00000239830	ENSP00000446093	Coiled-coil domain containing 77	Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.680
CDKN3	AURKAIP1	ENSP00000335357	ENSP00000342676	Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at ’Thr-160’ in a cyclin-dependent manner; CDC14 phosphatases	Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation	0.653
CDKN3	CCDC124	ENSP00000335357	ENSP00000471455	Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at ’Thr-160’ in a cyclin-dependent manner; CDC14 phosphatases	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	0.568

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