| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATOX1 | ATP7A | ENSP00000430598 | ENSP00000345728 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense; Belongs to the ATX1 family | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells; ATPase copper transporting | 0.999 |
| ATOX1 | PDZD11 | ENSP00000430598 | ENSP00000239666 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense; Belongs to the ATX1 family | PDZ domain containing 11 | 0.905 |
| ATP7A | ATOX1 | ENSP00000345728 | ENSP00000430598 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells; ATPase copper transporting | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense; Belongs to the ATX1 family | 0.999 |
| ATP7A | PDZD11 | ENSP00000345728 | ENSP00000239666 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells; ATPase copper transporting | PDZ domain containing 11 | 0.969 |
| ATP7A | WDFY2 | ENSP00000345728 | ENSP00000298125 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells; ATPase copper transporting | WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By sim [...] | 0.422 |
| DCAF16 | METTL15 | ENSP00000371682 | ENSP00000384369 | DDB1- and CUL4-associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase | 0.657 |
| DCAF16 | PDZD11 | ENSP00000371682 | ENSP00000239666 | DDB1- and CUL4-associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | PDZ domain containing 11 | 0.637 |
| KIF4A | PDZD11 | ENSP00000363524 | ENSP00000239666 | Chromosome-associated kinesin KIF4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization; Kinesins | PDZ domain containing 11 | 0.771 |
| METTL15 | DCAF16 | ENSP00000384369 | ENSP00000371682 | Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase | DDB1- and CUL4-associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.657 |
| METTL15 | PDZD11 | ENSP00000384369 | ENSP00000239666 | Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase | PDZ domain containing 11 | 0.639 |
| NEURL1B | PDZD11 | ENSP00000358815 | ENSP00000239666 | E3 ubiquitin-protein ligase NEURL1B; E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands; Ring finger proteins | PDZ domain containing 11 | 0.622 |
| NEURL1B | RPS27A | ENSP00000358815 | ENSP00000272317 | E3 ubiquitin-protein ligase NEURL1B; E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands; Ring finger proteins | Ubiquitin-40S ribosomal protein S27a; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be inv [...] | 0.900 |
| PDZD11 | ATOX1 | ENSP00000239666 | ENSP00000430598 | PDZ domain containing 11 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense; Belongs to the ATX1 family | 0.905 |
| PDZD11 | ATP7A | ENSP00000239666 | ENSP00000345728 | PDZ domain containing 11 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells; ATPase copper transporting | 0.969 |
| PDZD11 | DCAF16 | ENSP00000239666 | ENSP00000371682 | PDZ domain containing 11 | DDB1- and CUL4-associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.637 |
| PDZD11 | KIF4A | ENSP00000239666 | ENSP00000363524 | PDZ domain containing 11 | Chromosome-associated kinesin KIF4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization; Kinesins | 0.771 |
| PDZD11 | METTL15 | ENSP00000239666 | ENSP00000384369 | PDZ domain containing 11 | Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase | 0.639 |
| PDZD11 | NEURL1B | ENSP00000239666 | ENSP00000358815 | PDZ domain containing 11 | E3 ubiquitin-protein ligase NEURL1B; E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands; Ring finger proteins | 0.622 |
| PDZD11 | PLEKHA5 | ENSP00000239666 | ENSP00000404296 | PDZ domain containing 11 | Pleckstrin homology domain containing A5 | 0.580 |
| PDZD11 | RPS27A | ENSP00000239666 | ENSP00000272317 | PDZ domain containing 11 | Ubiquitin-40S ribosomal protein S27a; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be inv [...] | 0.568 |
