TTLL2 protein (human) - STRING database

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TTLL2

Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Tubulin tyrosine ligase family (592 aa)

Predicted Functional Partners:

TCP10L2

0.676

TCP10

0.624

UNC93A

0.589

FAM71E2

0.559

C6orf118

0.516

C6orf120

0.476

FAM200B

0.473

FAM200A

0.473

GPR31

0.469

PRR18

0.465

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6orf118	C6orf120	ENSP00000230301	ENSP00000346931	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	0.578
C6orf118	GPR31	ENSP00000230301	ENSP00000355799	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B; G protein-coupled receptors, Class A orphans	0.424
C6orf118	PRR18	ENSP00000230301	ENSP00000319590	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	Proline-rich protein 18; Proline rich 18	0.670
C6orf118	TCP10	ENSP00000230301	ENSP00000380929	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	T-complex protein 10A homolog; T-complex 10	0.507
C6orf118	TCP10L2	ENSP00000230301	ENSP00000355797	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	T-complex protein 10A homolog 2; T-complex 10 like 2; Belongs to the TCP10 family	0.656
C6orf118	TTLL2	ENSP00000230301	ENSP00000239587	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Tubulin tyrosine ligase family	0.516
C6orf118	UNC93A	ENSP00000230301	ENSP00000230256	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	Unc-93 homolog A; Belongs to the unc-93 family	0.541
C6orf120	C6orf118	ENSP00000346931	ENSP00000230301	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118	0.578
C6orf120	GPR31	ENSP00000346931	ENSP00000355799	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B; G protein-coupled receptors, Class A orphans	0.412
C6orf120	PRR18	ENSP00000346931	ENSP00000319590	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	Proline-rich protein 18; Proline rich 18	0.544
C6orf120	TCP10	ENSP00000346931	ENSP00000380929	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	T-complex protein 10A homolog; T-complex 10	0.474
C6orf120	TCP10L2	ENSP00000346931	ENSP00000355797	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	T-complex protein 10A homolog 2; T-complex 10 like 2; Belongs to the TCP10 family	0.634
C6orf120	TTLL2	ENSP00000346931	ENSP00000239587	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Tubulin tyrosine ligase family	0.476
C6orf120	UNC93A	ENSP00000346931	ENSP00000230256	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes	Unc-93 homolog A; Belongs to the unc-93 family	0.511
FAM200A	FAM71E2	ENSP00000411372	ENSP00000398617	Protein FAM200A; Family with sequence similarity 200 member A; Belongs to the FAM200 family	Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family	0.647
FAM200A	TTLL2	ENSP00000411372	ENSP00000239587	Protein FAM200A; Family with sequence similarity 200 member A; Belongs to the FAM200 family	Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Tubulin tyrosine ligase family	0.473
FAM200B	FAM71E2	ENSP00000483930	ENSP00000398617	Protein FAM200B; Family with sequence similarity 200 member B; Belongs to the FAM200 family	Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family	0.647
FAM200B	TTLL2	ENSP00000483930	ENSP00000239587	Protein FAM200B; Family with sequence similarity 200 member B; Belongs to the FAM200 family	Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Tubulin tyrosine ligase family	0.473
FAM71E2	FAM200A	ENSP00000398617	ENSP00000411372	Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family	Protein FAM200A; Family with sequence similarity 200 member A; Belongs to the FAM200 family	0.647
FAM71E2	FAM200B	ENSP00000398617	ENSP00000483930	Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family	Protein FAM200B; Family with sequence similarity 200 member B; Belongs to the FAM200 family	0.647

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