node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf49 | CCDC170 | ENSP00000367878 | ENSP00000239374 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Coiled-coil domain containing 170 | 0.771 |
C11orf49 | MFSD5 | ENSP00000367878 | ENSP00000442688 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily | 0.595 |
C6orf211 | CCDC170 | ENSP00000356263 | ENSP00000239374 | Protein-glutamate O-methyltransferase; O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response | Coiled-coil domain containing 170 | 0.788 |
C6orf211 | ESR1 | ENSP00000356263 | ENSP00000405330 | Protein-glutamate O-methyltransferase; O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.405 |
C6orf211 | RMND1 | ENSP00000356263 | ENSP00000356272 | Protein-glutamate O-methyltransferase; O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response | Required for meiotic nuclear division protein 1 homolog; Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome; Belongs to the RMD1/sif2 family | 0.841 |
CCDC170 | C11orf49 | ENSP00000239374 | ENSP00000367878 | Coiled-coil domain containing 170 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.771 |
CCDC170 | C6orf211 | ENSP00000239374 | ENSP00000356263 | Coiled-coil domain containing 170 | Protein-glutamate O-methyltransferase; O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response | 0.788 |
CCDC170 | EIF6 | ENSP00000239374 | ENSP00000363574 | Coiled-coil domain containing 170 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...] | 0.589 |
CCDC170 | ENTHD2 | ENSP00000239374 | ENSP00000300714 | Coiled-coil domain containing 170 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network | 0.599 |
CCDC170 | ESR1 | ENSP00000239374 | ENSP00000405330 | Coiled-coil domain containing 170 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.592 |
CCDC170 | MFSD5 | ENSP00000239374 | ENSP00000442688 | Coiled-coil domain containing 170 | Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily | 0.573 |
CCDC170 | NWD2 | ENSP00000239374 | ENSP00000309501 | Coiled-coil domain containing 170 | NACHT and WD repeat domain containing 2 | 0.620 |
CCDC170 | PDXDC1 | ENSP00000239374 | ENSP00000379691 | Coiled-coil domain containing 170 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family | 0.640 |
CCDC170 | RMND1 | ENSP00000239374 | ENSP00000356272 | Coiled-coil domain containing 170 | Required for meiotic nuclear division protein 1 homolog; Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome; Belongs to the RMD1/sif2 family | 0.816 |
CCDC170 | SYNE1 | ENSP00000239374 | ENSP00000356224 | Coiled-coil domain containing 170 | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrososme attachment and nuclear migrati [...] | 0.562 |
EIF6 | CCDC170 | ENSP00000363574 | ENSP00000239374 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...] | Coiled-coil domain containing 170 | 0.589 |
ENTHD2 | CCDC170 | ENSP00000300714 | ENSP00000239374 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network | Coiled-coil domain containing 170 | 0.599 |
ENTHD2 | NWD2 | ENSP00000300714 | ENSP00000309501 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network | NACHT and WD repeat domain containing 2 | 0.623 |
ESR1 | C6orf211 | ENSP00000405330 | ENSP00000356263 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Protein-glutamate O-methyltransferase; O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response | 0.405 |
ESR1 | CCDC170 | ENSP00000405330 | ENSP00000239374 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Coiled-coil domain containing 170 | 0.592 |