node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCAP29 | LRP11 | ENSP00000368414 | ENSP00000239367 | B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity); Belongs to the BCAP29/BCAP31 family | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.460 |
GDAP1L1 | LRP11 | ENSP00000440498 | ENSP00000239367 | Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.491 |
GDAP1L1 | RUNDC3A | ENSP00000440498 | ENSP00000410862 | Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1 | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells; Belongs to the RUNDC3 family | 0.631 |
LRP11 | BCAP29 | ENSP00000239367 | ENSP00000368414 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity); Belongs to the BCAP29/BCAP31 family | 0.460 |
LRP11 | GDAP1L1 | ENSP00000239367 | ENSP00000440498 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1 | 0.491 |
LRP11 | LRP12 | ENSP00000239367 | ENSP00000276654 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family | 0.520 |
LRP11 | LRP1B | ENSP00000239367 | ENSP00000374135 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.574 |
LRP11 | LRP2 | ENSP00000239367 | ENSP00000263816 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] | 0.451 |
LRP11 | LRP3 | ENSP00000239367 | ENSP00000253193 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 3; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro; Belongs to the LDLR family | 0.539 |
LRP11 | LRP8 | ENSP00000239367 | ENSP00000303634 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brai [...] | 0.487 |
LRP11 | PPP1R14C | ENSP00000239367 | ENSP00000355260 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | 0.634 |
LRP11 | RUNDC3A | ENSP00000239367 | ENSP00000410862 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells; Belongs to the RUNDC3 family | 0.440 |
LRP11 | SORL1 | ENSP00000239367 | ENSP00000260197 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Sortilin-related receptor; Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide [...] | 0.506 |
LRP12 | LRP11 | ENSP00000276654 | ENSP00000239367 | Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.520 |
LRP1B | LRP11 | ENSP00000374135 | ENSP00000239367 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.574 |
LRP2 | LRP11 | ENSP00000263816 | ENSP00000239367 | Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.451 |
LRP3 | LRP11 | ENSP00000253193 | ENSP00000239367 | Low-density lipoprotein receptor-related protein 3; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.539 |
LRP8 | LRP11 | ENSP00000303634 | ENSP00000239367 | Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brai [...] | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.487 |
PPP1R14C | LRP11 | ENSP00000355260 | ENSP00000239367 | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | 0.634 |
RUNDC3A | GDAP1L1 | ENSP00000410862 | ENSP00000440498 | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells; Belongs to the RUNDC3 family | Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1 | 0.631 |